Aliquots

Glaucoma-causing mutations in the gene for myocilin reduce secretion of the protein into the aqueous humor, suggesting a new option for treatment. Read More

Researchers are developing imaging methods to predict patient outcome early in the course of chemotherapy for breast cancer – to allow clinicians to adjust therapy for patients who are not responding. Read More

A genetic variant that increases risk for atrial fibrillation also impacts the response to a common therapy for the heart rhythm disorder. Read More

Diseases associated with mutations and changes in expression of the protein caveolin may result from faulty trafficking of the protein to the cell surface. Read More

Antacids that block a certain enzyme pose a risk for a common cardiac problem in premature infants. Read More

A factor produced by most malignant cells can both promote and inhibit tumor growth – an insight that is critical to using cancer drugs developed to block this factor. Read More

Children with autism spectrum disorder are better at perceiving the motion of certain objects than are typically developing children their age. Read More

A component of the extracellular matrix that surrounds cells plays a role in insulin resistance and may be a good therapeutic target. Read More

The inner ear system that senses gravity and movement plays a role in bone remodeling – a finding that has clinical implications for space travel and for patients with inner ear disorders. Read More

A high-salt diet worsens the carcinogenic effects of Helicobacter pylori, a bacterium that colonizes the stomachs of half of the world’s population. Read More

A “profile” of the genes and regulatory networks that govern early heart valve development lay the groundwork for generating valves from a patient’s own cells. Read More

An antioxidant enzyme also functions as a tumor suppressor to limit cancer development in the esophagus. Read More

Vanderbilt researchers have developed a novel algorithm to improve results from proteomic studies. Read More

Eating fava beans increases dopamine in blood and urine, but does not stimulate urinary sodium excretion. Read More

An immune system factor associated with severe asthma may actually reduce asthma attacks induced by viral infections. Read More

Dietary variety – not high-fat or sugary foods – appears to stimulate overeating in a mouse model of an inherited obesity syndrome. Read More

A gene associated with cell survival and longevity may protect the kidney from acute injury. Read More

Dysfunction of the endothelial cells that line blood vessels may contribute to delirium and coma in critically ill patients – and could be a target for therapy. Read More

Targeting repair pathways in the lung’s air sacs may be a valuable therapeutic direction for pulmonary fibrosis – the scarring of lung tissue. Read More

Overexpression of a gene that is a common culprit in leukemia induces stem cell-like features in T cells, which may enable the cells to become cancerous. Read More