Aliquots
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Fishing for new anti-cancer drugs
Vanderbilt investigators used an in vivo screen in zebrafish to identify a potential new anti-cancer drug. Read MoreSep 18, 2013
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Mapping brain membrane proteins
New mass spectrometry imaging methods will enable studies of the distribution and identification of membrane proteins directly within tissues. Read MoreSep 16, 2013
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Cancer nanomedicines on target
Therapeutic nanoparticles may offer a powerful new way to image and treat cancer at the same time. Read MoreSep 13, 2013
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‘Proofreader’ key to coronavirus growth
A coronavirus protein is required for replication of the viral genome and may be a good treatment target for SARS and other diseases caused by coronaviruses. Read MoreSep 12, 2013
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Probing intestinal immune cell roles
A new in vitro system will allow investigators to explore how immune system T cells develop specialized functions. Read MoreAug 28, 2013
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Tumor factor spurs blood vessel growth
A newly identified factor regulates blood vessel growth in colorectal tumors and could be a promising target for cancer therapies. Read MoreAug 26, 2013
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Pregnancy promoter and protector
Alkaline phosphatase enzymes appear to play roles in promoting pregnancy and in protecting the uterus from bacterial infection. Read MoreAug 23, 2013
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Overcoming resistance in ovarian cancer
The nuclear receptor TR3 contributes to ovarian cancer cell death in response to platinum-based chemotherapy – and may be a good target for overcoming cell resistance to certain treatments. Read MoreAug 22, 2013
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Oxidative stress in autism
A biomarker for oxidative stress is elevated in patients with both autism spectrum disorder and gastrointestinal dysfunction, suggesting opportunities for individualized approaches to clinical care. Read MoreAug 14, 2013
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Noninvasive test detects stomach bug
A noninvasive test can be used to identify the presence of Helicobacter pylori and evaluate its virulence, which will be useful in areas with high rates of H. pylori-associated gastric cancer. Read MoreAug 12, 2013
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‘Yo-yo dieting’ inflames fat tissue
Gaining and losing weight during “yo-yo dieting” may contribute to an exaggerated immune response in fat tissue that increases metabolic dysfunction more than steady weight gain alone. Read MoreAug 9, 2013
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Nuclear shield against cell death
The protein SARM appears to protect cells from inflammation-driven death by stabilizing the nuclear laminin scaffold. Read MoreAug 8, 2013
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Factor’s role in long bone development
Insight into how the protein neurofibromin participates in the signaling pathway that produces the body’s long bones has implications for fracture healing in some patients. Read MoreJul 31, 2013
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Motor protein revs up cell division
A motor protein that helps drive cell division may be a promising new target for cancer therapeutics. Read MoreJul 29, 2013
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Reducing fatal rhythms after heart attack
Reducing heart muscle response to calcium could decrease the risk of fatal arrhythmias after heart attacks. Read MoreJul 26, 2013
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Visualizing data on network ‘maps’
The new web application NetGestalt will allow investigators to simultaneously visualize different types of data for the same gene – such as mutation, expression and modification. Read MoreJul 25, 2013
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Probing roles of a cell death protein
Vanderbilt researchers have discovered new roles for a protein involved in cell death processes that are activated to prevent tumor-causing DNA mutations. Read MoreJul 17, 2013
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Defining patient retention
Vanderbilt researchers propose guidelines for defining patient retention in clinical studies – an important parameter that affects study conclusions and program evaluations. Read MoreJul 15, 2013
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Methods for imaging myelin loss
Certain MRI metrics can be used to assess myelin loss in multiple sclerosis, which is important for planning and monitoring therapy. Read MoreJul 12, 2013
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Model for MADD mitochondrial disease
A zebrafish model of a severe mitochondrial disease will be useful for developing new therapeutic approaches. Read MoreJul 11, 2013