Aliquots

The pulmonary arterial hypertension knowledgebase (PAHKB), developed by Vanderbilt researchers, provides a useful tool for identifying PAH-related genes and signaling pathways relevant to pathogenesis. Read More

Targeting the enzyme FosB could make antibiotic-resistant staph bacteria sensitive to the antibiotic fosfomycin. Read More

Using imaging data, Vanderbilt researchers discovered an association between a gene pair and brain changes in Alzheimer’s disease. Read More

A new mouse model reveals gene clusters important in a treatment-resistant form of leukemia. Read More

Obesity causes peripheral immune cells to move to the brain, where they may contribute to inflammation and the pathophysiology of obesity. Read More

Variation in the gene for the beta-1 adrenergic receptor increases the risk that a patient will have an abnormal heart rhythm after cardiac surgery. Read More

Targeting the production of molecules that promote tumor blood vessel development offers a new path for treating lung cancer. Read More

The antioxidant vitamin E prevented the buildup of toxic products in a model of a rare genetic disorder, suggesting new strategies for therapeutic development. Read More

It might be possible to generate a “metabolically healthy” state of obesity by targeting signaling pathways that improve insulin sensitivity. Read More

A new computational model of the interactions between vocal folds and the air around them could aid in designing new treatments for voice disorders. Read More

Understanding the relationship between the thinning and rupture of fetal membranes and the presence of bacteria could lead to treatment and prevention strategies for premature birth. Read More

by Denise Anthony (iStock) A Vanderbilt University-led research team has solved a long-standing riddle: Why do people of mostly Amerindian ancestry in the Andes have a gastric cancer rate that is 25 times higher than that of fellow Colombians of mostly African descent only 124 miles away on the coast?… Read More

Understanding how HIV infection affects immune system B cells may guide strategies for vaccine development. Read More

Vanderbilt researchers describe a new technique for identifying factors that stimulate the proliferation of pancreatic beta cells – factors that might offer therapeutic options for diabetes. Read More

Vanderbilt researchers have discovered that variation in the gene encoding the potassium channel GIRK1 plays a role in modulating human pain perception. Read More

An association between rigid-compulsive behaviors and gastrointestinal symptoms in autism spectrum disorder may point to a common biological pathway that impacts both the brain and the gut. Read More

A metabolic enzyme plays a crucial role in vascular development and may be a good target for cancer therapies. Read More

The breast cancer drug tamoxifen improves cognitive performance in post-menopausal women. Read More

The protein CK1 delays cell division to avoid the generation of defects that drive tumorigenesis. Read More

A protein kinase linked to inflammation and tumor development may be a good target for gastric cancer therapies. Read More