Aliquots
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CaMKII enhances insulin secretion
The protein CaMKII acts as a calcium sensor in a positive feedback pathway that enhances glucose-stimulated insulin secretion. Read MoreMay 14, 2014
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Normalizing calcium flux to treat atrial fibrillation
A particular anti-arrhythmia drug provides a targeted treatment for certain forms of atrial fibrillation. Read MoreMay 12, 2014
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Bypassing DNA damage
Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage. Read MoreMay 9, 2014
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PET probe detects dying tumor cells
A novel PET imaging probe detects tumor cell death in vivo and could be useful for personalizing cancer medicine. Read MoreMay 8, 2014
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Potential mechanism for myeloma drug’s variable toxicity
A genetic variant is associated with toxicity of the chemotherapy drug melphalan, and could guide individualized dosing for the medication. Read MoreApr 30, 2014
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Target cell entry to halt Chikungunya virus
Understanding how chikungunya virus binds to and enters cells offers a new target for antiviral medications. Read MoreApr 28, 2014
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Increased cell permeability may protect from colitis
Having a “leaky” gut may protect against colitis, a paradoxical finding that alters understanding of the role of cell permeability in intestinal homeostasis and immune regulation. Read MoreApr 25, 2014
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New view of neurotransmitter transport
Dynamic measurements of the bacterial leucine transporter shed light on the transporters that play roles in neuropsychiatric and addiction disorders. Read MoreApr 24, 2014
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Channel drug restores glucose balance
A new compound that activates potassium channels could be used to treat disorders of glucose homeostasis. Read MoreApr 16, 2014
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Anthrax bacteria’s signaling systems
Vanderbilt researchers have identified a new signaling system that anthrax bacteria uses to infect its host. Read MoreApr 15, 2014
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Myelin junctions key to conduction
A protein in the myelin coating on nerves helps form a “seal” that enables effective nerve conduction; loss of the protein causes inherited neuropathies. Read MoreApr 11, 2014
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Matrix remodeling and insulin resistance
The extracellular matrix that surrounds cells plays a role in the development of insulin resistance. Read MoreApr 10, 2014
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Development and disease in the aorta
Smooth muscle cells that line the aorta differ in development but not in the adult, a finding that has implications for understanding aortic development and disease. Read MoreApr 2, 2014
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E-records shed light on drug response
Electronic medical records linked to DNA biobanks are a valid resource for defining and understanding the genetic factors that contribute to drug response. Read MoreMar 31, 2014
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Mapping brain circuitry
Vanderbilt investigators have used two types of neuroimaging to establish a “map” of connections for a brain region important in anxiety and addiction. Read MoreMar 28, 2014
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Flu boosts pneumococcal colonization
Influenza and parainfluenza infections – but not other respiratory viruses – increase the risk of acquiring pneumococcal bacteria, the most common cause of severe pneumonia. Read MoreMar 27, 2014
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Small molecule protects kidney filter
A compound identified at Vanderbilt has therapeutic potential in protecting the kidney filter barrier. Read MoreMar 19, 2014
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Delirium increases long-term disability
Patients who suffer a longer duration of delirium in the intensive care unit are more likely to experience long-term disability after discharge. Read MoreMar 17, 2014
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Protein boosts retinal neuron survival
An ion channel protein called TRIPV1 helps retinal neurons survive the elevated eye pressure associated with glaucoma. Read MoreMar 14, 2014
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A new way to target cancer-driver Ras
Vanderbilt researchers have discovered small molecules that turn off cancerous Ras signals in a new way. Read MoreMar 13, 2014