Aliquots

A genetic predisposition to Parkinson’s disease makes neurons more vulnerable to the toxicity of heavy metals such as copper. Read More

New findings suggest a previously unrecognized role for the Sox10 transcription factor in Hirschsprung’s disease, and may lead to improved diagnostic and therapeutic approaches for this disease. Read More

New studies explain how T-cell receptors use force to recognize and protect us against pathogens. Read More

Although heteromeric dopamine receptors composed of both D1 and D2 subunits have been proposed to play a role in depression and schizophrenia, recent studies suggest these heteromers do not exist. Read More

New findings explain why variation in a particular gene is the most important determinant of fasting blood glucose levels in humans. Read More

Alterations of the vestibular system - the part of our inner ear that controls balance - may contribute to bone loss related to both aging and space travel. Read More

Patients with orthostatic intolerance – problems when standing – have cognitive changes, even when seated, compared to healthy individuals. Read More

Growing evidence suggests that fish oil, thought to directly prevent inflammation, oxidative stress and heart disease, may have limited clinical utility. Read More

A protein that degrades the “matrix” between cells participates in the development of lung metastases from primary breast cancer in mouse models and may be a good target for breast cancer treatment. Read More

New findings suggest that misfolded proteins accumulate in the heart atria, particularly in patients with hypertension, and may contribute to atrial heart disease. Read More

A newly identified “atheroprotective” gene is a tool for exploring plaque pathophysiology and may be a good target for therapies to slow atherosclerosis progression. Read More

Understanding how the protein TRPV1 helps neurons survive after glaucoma-related stressors could lead to new therapeutic strategies for glaucoma and other neurodegenerative conditions. Read More

New structural findings reveal how "gatekeeper" proteins participate in the secretion systems bacteria use to infect host cells. Read More

Vanderbilt researchers have developed tools to probe the role of the essential metal manganese in neurons, and which offer a started point for developing therapeutic agents for manganese-related neurological disorders. Read More

Vanderbilt researchers have discovered a new target for the prevention of atherosclerotic plaque development and cardiovascular disease. Read More

A particular gene is associated with a specific type of inflammatory response in people with asthma – a finding that could suggest new therapeutic targets for treating asthma. Read More

Understanding how zinc and the host’s immune response control H. pylori’s cancer-causing potential could suggest new therapeutic strategies to reduce infection and cancer risk. Read More

A new mouse model offers insight into the signaling pathways that control oral cancers – and a platform for testing anticancer therapeutics. Read More

Vanderbilt investigators have used a computational biology approach to uncover new cancer drivers and biomarkers of anticancer drug response. Read More

An overactive stress response contributes to the development of insulin resistance in obese individuals, and blocking it may be therapeutically beneficial. Read More