Aliquots

To most effectively use electronic health records for research, investigators should query multiple components of the record to identify patients with specific diseases. Read More

A compound acting on serotonin receptors delays a critical step during reovirus cell entry, reducing viral infectivity. Read More

Vanderbilt investigators have defined a gene expression program that controls the timing of synaptic remodeling – a process that is critical to brain development, learning and memory. Read More

A signaling factor called Wnt10b is a novel target for optimizing cardiac repair after a heart attack. Read More

Understanding the action of a certain enzyme will shed light on basement membrane function, and on disorders ranging from diabetic kidney disease to cancer. Read More

Understanding how macrophage immune cells accumulate in fat tissue and contribute to the pathology of obesity could lead to the development of novel therapeutics for metabolic disorders. Read More

Dietary vitamin C may maintain healthy blood vessels in patients with inflammatory diseases. Read More

Understanding how signaling molecules are transported within and out of the cell may help to uncover the causes of certain cancers. Read More

Vanderbilt investigators have developed a framework for studying cellular responses that could be used to identify the agents driving a range of biological processes in health and disease. Read More

Vanderbilt investigators have discovered how mammals, including humans, produce the painkiller morphine. Read More

Functional magnetic resonance imaging has revealed faulty circuits between the thalamus – a central hub of brain activity – and other brain regions. Read More

The factor FoxM1 increases the proliferation and function of insulin-producing beta cells, making it an attractive therapeutic target for diabetes. Read More

Vanderbilt researchers are exploring how neuroblastoma tumors begin and progress, knowledge that could provide new treatments for this pediatric cancer. Read More

Drugs that target DNA damage improve ovarian cancer cell response to platinum chemotherapies, suggesting new therapeutic opportunities. Read More

Vanderbilt researchers have discovered how certain molecules with antibiotic properties are synthesized, findings that could lead to new drugs that overcome the increased antibiotic resistance in bacteria. Read More

Vanderbilt scientists have discovered a new molecular mechanism that promotes stomach cancer development, findings that could provide new opportunities for treatment. Read More

Vanderbilt investigators demonstrate that a certain eye lens protein is evolutionarily conserved between zebrafish and rat, suggesting that zebrafish can be used as a model system to understand eye lens disorders such as cataracts. Read More

Compounds found in olives and olive oil have anticancer activity, which may contribute to the cancer preventive properties attributed to the Mediterranean diet. Read More

Vanderbilt investigators have discovered how human antibodies induced during testing of an experimental “bird flu” vaccine kill the virus. Read More

The rigidity of the bone extracellular matrix increases the ability of tumor cells to destroy bone, suggesting new targets for anticancer drug development. Read More