Aliquots

Defining the genes required for the function of insulin-producing beta cells is crucial for ongoing efforts to develop a cell-based therapy for diabetes. Read More

New findings identify isoketal-modified proteins as a previously unrecognized feature of pulmonary fibrosis and as a potential therapeutic target for this disease. Read More

Vanderbilt researchers have identified biomarkers that could be useful for evaluating and treating pregnancy-related heart failure. Read More

A genetic risk factor for Alzheimer’s disease in later life appears to benefit younger adults as they age. Read More

Collybolide – a natural product isolated from a mushroom – is a promising candidate for the development of non-addictive pain medicines. Read More

COX-2 inhibitors – used clinically to reduce inflammation and pain – may find new applications for treating PTSD and other stress-related psychiatric disorders like major depression. Read More

Vanderbilt researchers have discovered that activation of a certain signaling pathway protects brain cancers from targeted therapies, suggesting that using therapeutics that block both pathways may be a promising treatment. Read More

A newly discovered mechanism that helps cancer cells avoid destruction by immune system cells may improve immunotherapies. Read More

A genetic mutation that promotes cancer development blocks the normal sorting of a protein called “Argonaute 2.” Read More

New structural details of the binding of the bacterium Streptococcus sanguinis to platelets may offer new therapeutics for life-threatening cardiovascular infections. Read More

Vanderbilt researchers show that two factors promote the repair of myelin, the nerve cell covering that deteriorates in diseases such as multiple sclerosis. Read More

Vanderbilt investigators have discovered details about the mechanism of an important DNA repair protein that maintains genome stability. Read More

Signaling by a receptor that is overexpressed in aggressive forms of breast cancer has been linked to glutamine metabolism, suggesting new anti-cancer therapeutic targets. Read More

Adherence to medication was the only self-care activity independently associated with glycemic control in a low-income population. Read More

Vanderbilt researchers show that a certain factor negatively impacts the first-line responder cells in the lungs, providing one explanation for why patients with asthma are at greater risk for invasive bacterial disease. Read More

The p73 gene is required for the generation of cilia – hair-like projections on cells – findings that could have implications for the study of lung diseases and sterility. Read More

A new epidemiological study supports smoking cessation and avoidance of sedentary lifestyle as cancer prevention measures. Read More

Using patients’ health records to assess preparedness for hospital discharge is more effective at predicting readmission or death than commonly used questionnaires. Read More

A new biological therapy, ustekinumab, improves markers of disease activity in patients with severe Crohn’s disease. Read More

A new compound developed at Vanderbilt treats multiple symptoms of schizophrenia in an animal model, without causing sedation. Read More