Aliquots

Elevated levels of the factor G-CSF appear to promote the development of aggressive pancreatic cancer, suggesting a new therapeutic approach for this devastating disease. Read More

Vanderbilt investigators have discovered that oxidative damage may play an important role in the development of a rare cholesterol synthesis disease and in the behavioral changes of autism spectrum disorders. Read More

Vanderbilt researchers have found that red blood cell membrane fatty acid content is associated with risk of having colorectal adenomas, with omega-6 fatty acids increasing and omega-3 fatty acids decreasing risk. Read More

Assessing brain functional and structural connectivity in patients with temporal lobe epilepsy may be a useful way to identify the best candidates for surgical treatment. Read More

Based on findings from Vanderbilt investigators and others, clinical trials of estrogen inhibition for pulmonary arterial hypertension have recently been approved and funded by the National Institutes of Health. Read More

New findings could explain the link between chronic stress and reduced survival in women diagnosed with breast cancer, and could lead to new strategies to improve treatment outcomes. Read More

Using bioinformatics approaches, Vanderbilt investigators have identified gene expression networks that are deregulated in mouse and human stomach cancers. Read More

Although drug addiction is classically studied in a neuron-centric way, Vanderbilt researchers have discovered that the immune system also plays a critical role. Read More

The histone deacetylase HDAC3 is required for the maturation of B cells, white blood cells that produce antibodies. Read More

Vanderbilt researchers report a structure of a human metabolic enzyme bound to its substrate 17alpha-hydroxyprogesterone. Read More

The hormone erythropoietin (Epo) controls red blood cell production and synthetic forms of Epo treat multiple disorders. New Vanderbilt research details how Epo works. Read More

Vanderbilt researchers have found that non-coding regions of the genome appear to contribute to the risk of autoimmune diseases and may represent attractive therapeutic targets. Read More

Signaling through a complex of proteins called mTORC2 plays a role in breast cancer migration, invasion and metastasis, Vanderbilt researchers reported. Read More

Bile acids produced by a western diet alter the composition of the gut microbiota and promote intestinal carcinogenesis. Read More

The identification of a genetic culprit for hypoplastic left heart syndrome could lead to new treatments for the condition. Read More

A signaling molecule called interleukin-6 may be a therapeutic target to prevent vision loss or nerve degeneration in glaucoma, Vanderbilt researchers have discovered. Read More

Vanderbilt investigators have conducted a first-of-its-kind genome-wide association study of lung cancer survival in African-Americans. Read More

A novel immunotherapy combination induced remarkable regression of tumors in a mouse model of head and neck cancer. Read More

A PET probe that detects the amino acid glutamine predicts whether tumors respond to certain targeted therapies in preclinical animal models. Read More

New findings shed light on how enzymes that replicate DNA skip over mutations that might cause cancer and restart DNA synthesis further away. Read More