Research

Researchers at Vanderbilt University Medical Center and colleagues have identified a gene that increases the risk for a severe and potentially life-threatening reaction to the commonly prescribed antibiotic vancomycin. Read More

Loss of the protein STK17A may contribute to metastasis of colorectal cancer. Read More

People with low levels of endocannabinoids, which stimulate the same brain receptors turned on by the active ingredient in marijuana, experience greater pain relief from opioids than those with high levels. Read More

A team of Vanderbilt University chemists started decoding the total human molecular picture by examining 456 variations of one class of molecule, lipids. Read More

A big-data analysis of patient records at Vanderbilt University has found a link specifically between Celebrex and heart valve calcification. Read More

The brain endothelial barrier had previously been generated from induced pluripotent stem cells in a two-dimensional culture but not validated in three-dimensional, vein-like structures that are necessary to feed the organoids. Read More

In addition to establishing potency, the team’s tests on cells and, later, mice showed that even high doses of the compound caused no ill effects. Read More

Identifying and quantifying skin lesions often requires hours of tedious visual inspection by experts, making it difficult to study a lot of them at once. Eric Tkaczyk and Daniel Fabbri have found that training multiple non-experts to do basic evaluations can achieve comparable results. Read More

A monoclonal antibody against the chikungunya virus developed by researchers at Vanderbilt University Medical Center is the first monoclonal antibody encoded by messenger RNA to enter a clinical trial. Read More

An international team involving Vanderbilt researchers has discovered that a new “checkpoint” protein on immune system cells is active in tumors, and that blocking it — in combination with other treatments — is a successful therapeutic approach in mouse models of cancer. Read More

Frogs don’t like living near noisy highways any better than people do, but research from Vanderbilt suggests that frogs, like hardened city-dwellers, can learn to adapt to the constant din of rumbling trucks, rolling tires and honking horns. Read More

Vanderbilt University Medical Center recently received a $3.9 million grant from the National Institutes of Health to improve outcomes for children with significant hearing loss by providing individualized, prescription-like programming for their cochlear implants. Read More

Drug combinations used for the treatment of non-small-cell lung cancer (NSCLC) and melanoma aren’t as effective as they could be. Oncologists haven’t had the right tools to predict drug interactions, other than in costly clinical trials. That could change with a new algorithm developed by a cross-disciplinary Vanderbilt University team… Read More

Middle Tennessee children with autism spectrum disorder are 2.5 times more likely than children without ASD to be reported to the Child Abuse Hotline by age 8. Read More

Matthew Tyska and colleagues have found that an adhesion protein in the gut is necessary for proper intestinal functioning. Read More

Danny Winder and colleagues have demonstrated how norepinephrine and a stress factor call CRF interact, which may lead to new treatments for stress-related disorders. Read More

Lawrence Marnett and colleagues have demonstrated how two enzymes cooperate to maintain even levels of an important cellular signaling molecule. Read More

Timothy Cover, john Loh and colleagues have identified how a certain type of mutation influences the risk of premalignant and malignant changes in the stomach. Read More

Inhibiting COX-2 — an enzyme associated with inflammation — could provide a novel therapeutic approach for stress-related psychiatric disorders. Read More

Legal immigrants with darker skin are paid up to 25 percent less than those with lighter skin, a wage penalty that widened significantly several years after receiving permanent legal status. Read More