Leigh MacMillan

Abnormal levels of fatty acids in the blood and tissues of patients with cystic fibrosis may be reversed by supplementation with the fatty acids DHA and EPA. Read More

New details on the DNA-cutting activity of topoisomerase II, a target of anti-cancer drugs, could lead to better chemotherapeutic agents. Read More

Vanderbilt researchers have discovered a new molecular participant in the Wnt signaling pathway, which plays important roles in cell growth, development and cancer. Read More

Signaling pathway discoveries suggest ways to induce stem cells to become cardiac muscle cells, which could be useful for regenerating damaged heart muscle. Read More

Brain deficits are not present in the early stages of schizophrenia, suggesting it may be possible to delay or prevent the development of brain abnormalities. Read More

ResearchMatch.org is a web-based registry that is connecting participants and researchers for clinical studies. Read More

A new analytical tool points to genes that act together to increase disease risk. Read More

Individuals who are outside the normal range of expression for the adenomatous polyposis coli (APC) gene have an increased risk of colorectal cancer, according to a study published in the January issue of Gastroenterology. Read More

Therapeutic agents focusing on the brain region involved in stress-induced relapse may be effective in preventing relapse in patients with alcohol use disorders. Read More

The discovery of a previously unrecognized and pivotal role of enzyme ASL in nitric oxide production could potentially lead to new therapies for babies with pulmonary hypertension. Read More

A strain of mutant mice provide a novel model for studying glucose intolerance and gestational diabetes during pregnancy and suggest that certain molecules may be useful for therapeutic applications. Read More

Managing myocardial infarction – and the resulting heart failure – remains a clinical challenge. To search for chemicals that can stimulate cardiac muscle cell production, Vanderbilt Institute of Chemical Biology investigators led by Tao Zhong, Ph.D., Terri Ni, Ph.D., and Eric Rellinger, M.D., turned to a novel drug discovery tool:… Read More

Images of individuals with Alagille syndrome (National Institutes of Health) Mutations in the Jagged1 gene cause Alagille syndrome, an inherited disorder that affects the liver, heart, kidneys and facial structure. Patients with Alagille syndrome often have a prominent forehead, a flattened midface and a prominent chin; some have a cleft… Read More

Ela Knapik, associate professor of medicine, and colleagues are using zebrafish to explore the molecular and cellular mechanisms that cause birth defects of the face and skeleton. Read More

Compounds developed at Vanderbilt could offer a whole new way to treat atherosclerosis. Read More

Recreational use of the "rave" drug Ecstasy is associated with chronic changes in the human brain. Read More

Structural biology studies of a bacterial protein suggest a new target for treating life-threatening heart infection. Read More

A new mouse model provides a tool for testing novel therapeutic approaches for neurofibromatosis. Read More

Providing increased mentorship, research opportunities and a nurturing, intellectual environment during fellowship training may help reduce a projected shortage of academic hematologists and oncologists. Read More

Vanderbilt researchers have identified an antigen important to balancing the immune response to bacteria in the gut. Read More