Leigh MacMillan

An antioxidant enzyme also functions as a tumor suppressor to limit cancer development in the esophagus. Read More

Nobel laureate Michael Brown, M.D., describes his quest to understand cholesterol during the 2013 Earl W. Sutherland lecture. (Photo by Susan Urmy) Cholesterol is a tricky molecule to keep in balance. It’s a building block for the cell membrane and is required for cell growth and survival. Read More

Vanderbilt researchers have developed a novel algorithm to improve results from proteomic studies. Read More

Eating fava beans increases dopamine in blood and urine, but does not stimulate urinary sodium excretion. Read More

An immune system factor associated with severe asthma may actually reduce asthma attacks induced by viral infections. Read More

Nobel laureate Michael Brown, M.D., whose research paved the way for the development of cholesterol-lowering statin drugs, will deliver the next Flexner Discovery Lecture on Thursday, April 25. Read More

After 40 years in basic science working with yeast cells, Nobel laureate Lee Hartwell, Ph.D., has turned his attention in a new direction. Read More

A gene associated with cell survival and longevity may protect the kidney from acute injury. Read More

Dysfunction of the endothelial cells that line blood vessels may contribute to delirium and coma in critically ill patients – and could be a target for therapy. Read More

Targeting repair pathways in the lung’s air sacs may be a valuable therapeutic direction for pulmonary fibrosis – the scarring of lung tissue. Read More

Overexpression of a gene that is a common culprit in leukemia induces stem cell-like features in T cells, which may enable the cells to become cancerous. Read More

Nobel laureate Lee Hartwell, Ph.D., will deliver the next Flexner Discovery Lecture on Thursday, April 11. Read More

Immune cells that recognize self antigens (e.g. insulin), but are functionally silent, can trigger autoimmune diseases such as diabetes. Read More

The gene Has2 participates in signaling that is important in developing fingers and toes, and may have relevance for cancer development. Read More

Berberine, an herbal remedy for diarrhea and intestinal parasites, may be useful in colon cancer therapy. Read More

Sir Rory Collins, MB BS, professor of Medicine and Epidemiology at the University of Oxford, England, will deliver the next Flexner Discovery Lecture on Thursday, April 4. Read More

In critically ill patients with sepsis, plasma hemoglobin may be a new indicator of disease severity – and a potential target for treatment with acetaminophen. Read More

A novel class of drugs that target “BET” proteins may have broad utility for treating genetically diverse brain tumors. Read More

The factor IRF6 plays important roles in the development of the tongue. Read More

Diagnostic codes used for billing purposes effectively identify smokers in a general clinic population and can be used to adjust smoking status in genetic and epidemiologic studies. Read More