Leigh MacMillan

Glaucoma-causing mutations in the gene for myocilin reduce secretion of the protein into the aqueous humor, suggesting a new option for treatment. Read More

Researchers are developing imaging methods to predict patient outcome early in the course of chemotherapy for breast cancer – to allow clinicians to adjust therapy for patients who are not responding. Read More

A genetic variant that increases risk for atrial fibrillation also impacts the response to a common therapy for the heart rhythm disorder. Read More

Osteomyelitis, a debilitating bone infection most frequently caused by Staphylococcus aureus (“staph”) bacteria, is particularly challenging to treat. Read More

Diseases associated with mutations and changes in expression of the protein caveolin may result from faulty trafficking of the protein to the cell surface. Read More

Antacids that block a certain enzyme pose a risk for a common cardiac problem in premature infants. Read More

A factor produced by most malignant cells can both promote and inhibit tumor growth – an insight that is critical to using cancer drugs developed to block this factor. Read More

Clinical pharmacologist Jens Titze, M.D., and his colleagues have identified a new cast of cells and molecules that function in the skin to control sodium balance and blood pressure. Read More

A component of the extracellular matrix that surrounds cells plays a role in insulin resistance and may be a good therapeutic target. Read More

Vanderbilt University investigators have developed a new strategy for identifying the “bits” of a pathogen that spark a protective immune response. Read More

The annual Southeast Regional meeting of the Society for Developmental Biology, hosted by Vanderbilt for the first time since 2006, broke participant records with 163 investigators registered and 81 posters presented. Read More

Vanderbilt awarded 66 Ph.D. degrees to an accomplished group of students in Medical Center-related departments and programs. Read More

The inner ear system that senses gravity and movement plays a role in bone remodeling – a finding that has clinical implications for space travel and for patients with inner ear disorders. Read More

A high-salt diet worsens the carcinogenic effects of Helicobacter pylori, a bacterium that colonizes the stomachs of half of the world’s population. Read More

A “profile” of the genes and regulatory networks that govern early heart valve development lay the groundwork for generating valves from a patient’s own cells. Read More

An antioxidant enzyme also functions as a tumor suppressor to limit cancer development in the esophagus. Read More

Nobel laureate Michael Brown, M.D., describes his quest to understand cholesterol during the 2013 Earl W. Sutherland lecture. (Photo by Susan Urmy) Cholesterol is a tricky molecule to keep in balance. It’s a building block for the cell membrane and is required for cell growth and survival. Read More

Vanderbilt researchers have developed a novel algorithm to improve results from proteomic studies. Read More

Eating fava beans increases dopamine in blood and urine, but does not stimulate urinary sodium excretion. Read More

An immune system factor associated with severe asthma may actually reduce asthma attacks induced by viral infections. Read More