Bill Snyder

An investigational drug that binds bile acids in the stomach can reduce the severity of heartburn symptoms in patients with treatment-resistant gastroesophageal reflux disease (GERD) when combined with a proton pump inhibitor (PPI), a new study suggests. Read More

Roger Colbran and colleagues have discovered new molecular details about the function of an enzyme with a key role in shaping learning and memory. Read More

Post-transplantation diabetes mellitus (PTDM), a common complication of immunosuppressive drugs that are given to prevent transplant rejection, may be reversible and at least partially preventable, researchers at VUMC report. Read More

The John D. and Catherine T. MacArthur Foundation today unveiled a grant proposal from Vanderbilt University Medical Center (VUMC) as one of the highest-scoring proposals, designated as the “Top 100,” in its 100&Change competition for a single $100 million grant to help solve one of the world’s most critical societal challenges. Read More

A new algorithm for artificial intelligence-assisted calcium scoring can accurately determine cardiovascular risk across a range of CT scans and in a racially diverse population. Read More

A research team led by scientists at Vanderbilt University Medical Center has developed an antibody mixture that in animals is highly effective in blocking infection by the Ebola virus. Read More

Two Vanderbilt University pharmacologists have won prestigious awards from the American Society for Pharmacology and Experimental Therapeutics (ASPET). Read More

Beta-1 integrin, a critical component of epithelial extracellular matrix receptors, is essential for normal lung function in adulthood, researchers at VUMC have discovered. Read More

MYC is a family of three related proteins that are overexpressed in cancer and which contribute to an estimated 100,000 cancer deaths annually in the United States. Understanding how MYC works could lead to the development of new drugs that can effectively block MYC and stop many cancers in their tracks. Read More

Ege T. Kavalali, PhD, professor and acting chair of the Department of Pharmacology in the Vanderbilt University School of Medicine, has been elected a recipient of a prestigious Humboldt Research Award by the Alexander von Humboldt Foundation of Germany. Read More

VUMC scientists are redoubling their efforts to help people fight off bird flu. Their focus is H7N9, one of the most dangerous of the influenza viruses that have been transmitted from birds to humans. Read More

A drug used to treat and prevent HIV/AIDS is showing promise as a potential therapy for Alzheimer’s disease. Read More

Poorly functioning AMPARs have been linked to a wide range of neurological and psychiatric disorders including seizures, Alzheimer’s disease, major depression and autism spectrum disorder. Understanding how AMPARs are formed and operate is essential for the rational design of pharmacological compounds that, by tuning AMPAR activity up or down, could improve treatment of these conditions. Read More

To explore how fear becomes entrenched, VUMC researchers traveled down the precise neuronal pathways in the brains of mice that trigger fear responses, and which normally extinguish the behaviors once the danger has passed. Read More

Researchers at VUMC have taken a major step that could ultimately facilitate development of a new class of antidepressants which may relieve symptoms more rapidly and effectively and with fewer side effects than current medications. Read More

Structural details of a protein that is essential to normal brain function could improve treatments for epilepsy and other seizure disorders. Read More

A novel tool developed by Vanderbilt scientists protects animals from endotoxin shock and can be used for mechanistic analyses of inflammation due to microbial and other insults. Read More

Immune cells that produce an anti-inflammatory factor are enriched in fat tissue around the heart and may be good targets to improve heart attack outcomes. Read More

The human brain consists of perhaps as many as 1,000 trillion synapses, which transmit signals from one nerve cell to another with amazing speed, precision and plasticity. Read More

Vanderbilt investigators have linked genetic mutations in a single receptor to epilepsy, autism and intellectual disability. Read More