World-renowned vaccine expert whose lab is developing vaccines for flu, Ebola, Zika, and more.
James Crowe directs the Vanderbilt Vaccine Center, and his lab has a broad portfolio of work in the area of viral immunology and cell biology, with an aim to the discovery of mechanisms important to develop new vaccines. Crowe and his colleagues are on the cutting edge of developing innovative technologies for the isolation and study of antiviral antibodies and for significantly advancing, through their pioneering work in computational immunology, the rational design of vaccines and antibodies. They have isolated human monoclonal antibodies for many pathogenic viruses, including Zika, HIV, dengue, influenza, Ebola, West Nile, norovirus, respiratory syncytial virus (RSV) and rotavirus. Their research has led to patents and licensures for several neutralizing antibodies and vaccines, some of which have progressed to clinical trials. Crowe received his MD degree from the University of North Carolina at Chapel Hill, where he also completed his pediatrics residency. Following his clinical training, Dr. Crowe received five years of post-doctoral training in the laboratory of Infectious Diseases at the NIH. He completed infectious diseases fellowship training in 1996 at Vanderbilt and has run an independent laboratory at Vanderbilt since that time. In addition, Crowe directs two institutional core laboratories: the Human Immunology Core and the Flow Cytometry and Cell Sorting Core. His work has been published in over 150 publications in high-quality journals including, Nature, Science, Nature Medicine, Proceedings of the National Academy of Sciences USA, the New England Journal of Medicine, and JAMA. Crowe has been the recipient of investigator awards from the March of Dimes, American Society for Microbiology, Pediatric Infectious Diseases Society, and Society for Pediatric Research. He has been awarded the Judson Infectious Daland Prize of the American Philosophical Society, the Oswald Avery Award of the IDSA, the E. Mead Johnson Award for Excellence in Pediatrics, the 2007 Outstanding Investigator Award of the American Federation for Medical Research, and the 2010 Norman J. Siegel Award of the American Pediatric Society. He is an elected Fellow of AAM, AAAS, ASCI and AAP, IDSA, APS, and others. He was elected to the National Academy of Medicine in 2014.