Authors: Amanda K Fakira, Emily G Peck, Yutong Liu, Lindsay M Lueptow, Nikita A Trimbake, Ming-Hu Han, Erin S Calipari, Lakshmi A Devi
GPR83, the receptor for the neuropeptide PEN, exhibits high expression in the nucleus accumbens of the human and rodent brain, suggesting that it plays a role in modulating the mesolimbic reward pathway. However, the cell-type specific expression of GPR83, its functional impact in the reward pathway, and in drug reward-learning has not been fully explored. Using GPR83/eGFP mice, we show high GPR83 expression on cholinergic interneurons in the nucleus accumbens and moderate expression on ventral tegmental area dopamine neurons.
Authors: Amy R. Johnson, Kimberly C. Thibeault, Alberto J. Lopez, Emily G. Peck, L. Paul Sands, Christina M. Sanders, Munir Gunes Kutlu & Erin S. Calipari
While preclinical work has aimed to outline the neural mechanisms of drug addiction, it has overwhelmingly focused on male subjects. There has been a push in recent years to incorporate females into existing addiction models; however, males and females often have different behavioral strategies, making it important to not only include females, but to develop models that assess the factors that comprise female drug addiction.
Publisher: Alcohol and Alcoholism
Authors: Jennifer E Zachry, Amy R Johnson, Erin S Calipari
For many psychiatric disorders, such as anxiety, depression, and addiction, sex is a critical biological variable and women represent a particularly vulnerable population (Piccinelli and Wilkinson, 2000; Becker et al., 2017). While sex differences in the pervasiveness and prognosis of these disorders have long been known to exist, there are few instances where approaches to pharmacological treatment of these disorders differ between the sexes, which likely contributes to ineffective treatments in women.
Publisher: Journal of Neuroscience
Authors: Erin S. Calipari, Arthur Godino, Marine Salery, Diane M. Damez-Werno, Michael E. Cahill, Craig T. Werner, Amy M. Gancarz, Emily G. Peck, Zahra Jlayer, Jacqui Rabkin, Joseph A. Landry, Alexander C.W. Smith, Paola Defilippi, Paul J. Kenny, Yasmin L. Hurd, Rachael L. Neve, David M. Dietz and Eric J. Nestler
Addictive behaviors, including relapse, are thought to depend in part on long-lasting drug-induced adaptations in dendritic spine signaling and morphology in the nucleus accumbens (NAc). While the influence of activity-dependent actin remodeling in these phenomena has been studied extensively, the role of microtubules and associated proteins remains poorly understood. We report that pharmacological inhibition of microtubule polymerization in the NAc inhibited locomotor sensitization to cocaine and contextual reward learning.
Publisher: ACS Chemical Neuroscience
Authors: Samantha E Yohn, Jordan Galbraith, Erin S Calipari, P Jeffrey Conn
Accumulated data from clinical and preclinical studies suggest that, in drug addiction and states of overeating, such as obesity and binge eating disorder (BED), there is an imbalance in circuits that are critical for motivation, reward saliency, executive function, and self-control. Central to these pathologies and the extensive topic of this Review are the aberrations in dopamine (DA) and glutamate (Glu) within the mesolimbic pathway.