Zebrafish

An international research team has discovered a new genetic syndrome caused by mutation of a single gene and named it CATIFA, an acronym for its core symptoms. Read More

According to a new study, the tiny zebrafish may hold the secret to regenerating damaged retinas in humans. Read More

Studies of alpha-B crystallin in zebrafish could ultimately lead to improved treatment for cataracts and heart disease. Read More

Research into retinal regeneration in zebrafish has identified a signal that appears to trigger the self-repair process, raising the possibility of inducing retinal repair in human eyes. Read More

The hormone leptin regulates glucose balance, but not fat stores, in zebrafish. Read More

Vanderbilt investigators demonstrate that a certain eye lens protein is evolutionarily conserved between zebrafish and rat, suggesting that zebrafish can be used as a model system to understand eye lens disorders such as cataracts. Read More

Using revolutionary CRISPR technology, Vanderbilt investigators have developed a fast and simple method to simultaneously turn off multiple genes in order to study complex diseases. Read More

A zebrafish model of a rare genetic disease has revealed an unexpected regulatory pathway for cholesterol absorption and processing. Read More

Researchers at Vanderbilt University have discovered a new way to inhibit Hedgehog (Hh) signaling, an important regulatory pathway for vertebrate development – and cancer. Read More

Vanderbilt University researchers have created a zebrafish model of skeletal muscle insulin resistance that could help improve diabetes treatment. Read More

A metabolic enzyme plays a crucial role in vascular development and may be a good target for cancer therapies. Read More

Vanderbilt investigators used an in vivo screen in zebrafish to identify a potential new anti-cancer drug. Read More

A zebrafish model of a severe mitochondrial disease will be useful for developing new therapeutic approaches. Read More

A new method for creating genetic mutations that can be activated at certain times or in specific tissues will enable studies to probe gene function. Read More

A new screening tool – using glowing fish embryos – could identify therapeutics for myocardial hypertrophy and heart failure. Read More

Managing myocardial infarction – and the resulting heart failure – remains a clinical challenge. To search for chemicals that can stimulate cardiac muscle cell production, Vanderbilt Institute of Chemical Biology investigators led by Tao Zhong, Ph.D., Terri Ni, Ph.D., and Eric Rellinger, M.D., turned to a novel drug discovery tool:… Read More

Ela Knapik, associate professor of medicine, and colleagues are using zebrafish to explore the molecular and cellular mechanisms that cause birth defects of the face and skeleton. Read More

Scientists from the Vanderbilt Vision Research Center will present new findings at two national vision conferences in May. Read More

A zebrafish model of the genetic disease tuberous sclerosis complex will speed new discoveries. Read More