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Wnt signaling Archives

Lung diseases share molecular signature

Apr. 5, 2018—Lung diseases of infancy and aging share a molecular signature, pointing to a potential target for treatment and prevention.

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Structure of a stem cell niche

Feb. 28, 2018—Understanding the specialized environment where stem cells reside is important for developing stem-cell based regenerative therapies.

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A target to heal tiny lungs

Feb. 23, 2017—The protein beta-catenin may be a good target for therapies to treat lung disease that is a common complication of preterm birth.

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Colorectal cancer clues

Jan. 19, 2017—Although cancers arising from different areas of the large intestine are heterogeneous, they appear to use similar important tumorigenic pathways.

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Wound-healing scaffolds

Jan. 27, 2016—The elasticity of a scaffold used for healing skin wounds is a key factor in promoting regeneration versus scarring.

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Healing without scarring

Oct. 16, 2015—Drugs that inhibit the Wnt signaling pathway can regenerate injured skin and may be useful in treating fibromatosis, degenerative joint disease and cancer.

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Heart repair factor

Sep. 17, 2015—A signaling factor called Wnt10b is a novel target for optimizing cardiac repair after a heart attack.

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Therapeutic target for synovial sarcoma

Nov. 21, 2013—Inhibitors of a signaling pathway that is critical to synovial sarcoma tumorigenesis may be useful treatments for this aggressive cancer.

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Fishing for new anti-cancer drugs

Sep. 18, 2013—Vanderbilt investigators used an in vivo screen in zebrafish to identify a potential new anti-cancer drug.

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Long live the therapeutic stem cells

May. 17, 2012—Enhancing stem cell survival is key to improving cell-based therapies for regenerative medicine, and a new drug could help.

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Colon cancer’s cellular crossroads

Mar. 16, 2012—New information about signaling pathways involved in colorectal cancer could aid in assessing prognosis and identifying new therapeutic targets for the disease.

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Studies pinpoint new anti-cancer drug target

Feb. 23, 2012—Vanderbilt researchers have discovered a new molecular participant in the Wnt signaling pathway, which plays important roles in cell growth, development and cancer.

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