Vanderbilt Center For Bone Biology
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Bone matrix changes during aging
Changes to the bone matrix that occur during aging may point to novel targets for treating osteoporosis. Read MoreJan 10, 2020
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Stress may switch on bone “mets”
New findings could explain the link between chronic stress and reduced survival in women diagnosed with breast cancer, and could lead to new strategies to improve treatment outcomes. Read MoreAug 9, 2017
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Unal receives Orthopedic Research Society award
Mustafa Unal, Ph.D., a postdoctoral research fellow at Vanderbilt University School of Medicine, has been selected by the Orthopedic Research Society to receive its 2017 Alice L. Jee Young Investigator Award for work that potentially will improve the clinical assessment of bone strength and quality. Read MoreJun 15, 2017
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Diabetes study seeks to identify biomarkers for fracture risk
Medical studies have established that people with type 2 diabetes are more susceptible to fractures, but the biological process that weakens their bones is not understood. Read MoreOct 20, 2016
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Wound-healing scaffolds
The elasticity of a scaffold used for healing skin wounds is a key factor in promoting regeneration versus scarring. Read MoreJan 27, 2016
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VUMC study shifts thinking on how bone fractures heal
New findings show that fibrin, a protein that was thought to play a key role in fracture healing, is not required, shifting understanding of how fractures heal. Read MoreAug 13, 2015
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Targeting bone metastasis
The rigidity of the bone extracellular matrix increases the ability of tumor cells to destroy bone, suggesting new targets for anticancer drug development. Read MoreJul 23, 2015
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Neurofibromin fine-tunes bone growth
The protein neurofibromin acts as a brake in a signaling pathway that is important in bone development, Vanderbilt researchers have discovered. Read MoreMay 6, 2015
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Inner ear keeps bones strong
Alterations of the vestibular system - the part of our inner ear that controls balance - may contribute to bone loss related to both aging and space travel. Read MoreJan 14, 2015
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Physician-scientist is dream job for Vanderbilt’s Cassat
Jim Cassat, M.D., Ph.D., a pediatric infectious disease specialist who joined the Vanderbilt faculty this summer, loves taking care of children with bone infections and doing research to understand the host-pathogen interactions during these invasive infections. Read MoreDec 4, 2014
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Bone healing therapy for NF1 fractures
A combination treatment delivered to the site of fractures may improve bone healing in patients with the genetic disease neurofibromatosis type-1. Read MoreSep 11, 2014
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Aggressive bone cancers build more blood vessels
A subpopulation of bone cancer cells may be responsible for driving clinically aggressive behavior, suggesting new treatment options. Read MoreSep 3, 2014
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Novel treatment strengthens bones in genetic disease
An enzyme therapy may prevent skeletal abnormalities associated with the genetic disorder neurofibromatosis type-1, Vanderbilt investigators have discovered. Read MoreAug 7, 2014
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Factor impacts bone toughness
The factor ATF4 has a role in the toughness of bone and its resistance to fracture, suggesting new therapeutic targets. Read MoreJun 16, 2014
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Neurotransmitter’s role in bone balance
Removal of the neurotransmitter norepinephrine from the space outside cells plays an important role in the regulation of bone remodeling. Read MoreNov 7, 2013
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Factor’s role in long bone development
Insight into how the protein neurofibromin participates in the signaling pathway that produces the body’s long bones has implications for fracture healing in some patients. Read MoreJul 31, 2013
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Studies outline new model for staph bone infections
Osteomyelitis, a debilitating bone infection most frequently caused by Staphylococcus aureus (“staph”) bacteria, is particularly challenging to treat. Read MoreJun 20, 2013
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Inner ear’s role in bone remodeling
The inner ear system that senses gravity and movement plays a role in bone remodeling – a finding that has clinical implications for space travel and for patients with inner ear disorders. Read MoreMay 15, 2013
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‘Longevity’ gene has role in bone loss
A gene associated with long life participates in the normal regulation of bone remodeling and may have a role in bone loss associated with aging. Read MoreDec 6, 2012
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VU study finds stress fuels breast cancer metastasis to bone
Stress can promote breast cancer cell colonization of bone, Vanderbilt Center for Bone Biology investigators have discovered. Read MoreJul 18, 2012