TGF-beta
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Probiotic protection
A probiotic factor given early in life to mice prevented intestinal inflammation in adulthood, providing a rationale for probiotic intervention in individuals at high risk of developing inflammatory bowel disease. Read MoreMar 4, 2021
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Potential new cancer target
Vanderbilt researchers have discovered the involvement of a certain type of adenosine receptor in mediating signaling that supports tumor growth and metastasis. Read MoreJun 4, 2020
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Symposium honors Moses’ storied cancer research career
Members of the Vanderbilt University Medical Center (VUMC) community and others whose lives and careers have been influenced by legendary cancer investigator, educator and administrator Harold (Hal) Moses, M.D., have endowed the Linda and Harold L. Moses, M.D. Career Development Fund. Read MoreOct 19, 2017
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Colorectal cancer clues
Although cancers arising from different areas of the large intestine are heterogeneous, they appear to use similar important tumorigenic pathways. Read MoreJan 19, 2017
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Surprising finding in the kidney
TGF-beta signaling in the kidney was thought to be a target for reducing renal fibrosis, but Vanderbilt researchers report that fibrosis still occurs in the absence of TGF-beta signaling. Read MoreApr 16, 2015
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Enzyme affects tumor metastasis
A protein that degrades the “matrix” between cells participates in the development of lung metastases from primary breast cancer in mouse models and may be a good target for breast cancer treatment. Read MoreJan 8, 2015
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New insight on oral cancer culprits
A new mouse model offers insight into the signaling pathways that control oral cancers – and a platform for testing anticancer therapeutics. Read MoreNov 12, 2014
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Molecular ‘chat’ holds kidney fibrosis clues
A novel molecular “conversation” regulates kidney fibrosis – the final result of end-stage chronic kidney disease – suggesting new treatment options for this currently irreversible process. Read MoreJul 10, 2014
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Preventing hardened heart valves
Blocking a serotonin receptor may provide a novel therapy for heart valve disease. Read MoreDec 26, 2012
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Proteins guard against cancer spread
Targeting immune system proteins may keep prostate cancer from spreading to bone. Read MoreJul 24, 2012
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Smoking stokes cells’ cancer capacity
Cellular pathways altered by chronic exposure to cigarette smoke may reveal new biomarkers to assess smoking-induced lung cancer risk. Read MoreMar 23, 2012
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Colon cancer’s cellular crossroads
New information about signaling pathways involved in colorectal cancer could aid in assessing prognosis and identifying new therapeutic targets for the disease. Read MoreMar 16, 2012
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Drugs reverse lung cancer cell changes
Drugs that target “epigenetic” changes may help treat or slow the progression of lung cancer. Read MoreFeb 1, 2012