T Cell
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Study finds hallmarks of T cell exhaustion within hours of tumor exposure
Vanderbilt researchers found that that T cells become “exhausted” within hours of encountering a tumor, challenging existing ideas about how T cells become dysfunctional. Read MoreAug 3, 2023
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Study identifies key player in T cell “education”
New Vanderbilt research could inform therapeutic strategies for enhancing thymic function when desired — such as during aging, recovery from radiation therapy or chemotherapy, or other conditions that reduce T cell output. Read MoreSep 1, 2022
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Blood test figures in cancer risk for people with HIV
A Vanderbilt study found that, among adult patients with HIV, those who have lower counts of certain types of blood cells have a markedly higher risk of developing cancer. Read MoreMar 17, 2022
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CRISPR screen identifies new anti-inflammatory drug target
A novel CRISPR screen developed by Vanderbilt researchers identified a promising new target for anti-inflammatory therapeutics. Read MoreNov 11, 2021
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‘Pre-conditioning’ restores immune tolerance
A treatment targeting T-cell metabolism could reinvigorate immune tolerance mechanisms to combat autoimmune disease and transplant rejection, Vanderbilt researchers discovered. Read MoreSep 16, 2021
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HIV, diabetes and immune cells in fat
In HIV-positive individuals with diabetes, immune cells in fat are more proinflammatory and cytotoxic and may represent a therapeutic target for diabetes. Read MoreMar 18, 2021
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Key factors in HIV-1 replication
HIV-1, the virus that causes AIDS, exploits inositol phosphates in T cells to aid its own assembly and maturation — suggesting that targeting inositol phosphate binding could inhibit HIV-1 replication. Read MoreFeb 8, 2021
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Rational vaccine design
Understanding immunity generated by smallpox vaccine may hold lessons for COVID-19 vaccine development. Read MoreSep 22, 2020
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“Nur” target may aid arthritis treatment
Vanderbilt immunologists have discovered that the protein Nur77 is part of a control mechanism that guards against autoimmunity in natural killer T cells. Read MoreJul 13, 2020
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Madhur receives Presidential Early Career Award
Meena Madhur, MD, PhD, has received a Presidential Early Career Award for Scientists and Engineers. Read MoreJul 18, 2019
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Study identifies critical regulator of tumor-specific T cell differentiation
A study published June 17 in Nature offers clues as to why blocking inhibitory receptors on tumor-infiltrating T cells may not always work Read MoreJun 18, 2019
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Vanderbilt scientists test potential new way to treat anemia
Treatment of anemia caused by chronic kidney disease or other diseases often requires repeated — and costly — injections or infusions of an artificial form of the hormone erythropoietin (EPO), which stimulates production of red blood cells. Read MoreApr 10, 2018
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Pancreatic cancer development
Elevated levels of the factor G-CSF appear to promote the development of aggressive pancreatic cancer, suggesting a new therapeutic approach for this devastating disease. Read MoreAug 31, 2017