Scientific Reports

Vanderbilt research describes a new investigational peptide drug that can penetrate immune and nonimmune cells, and block inflammatory signaling in a preclinical model of atopic dermatitis — eczema. Read More

Understanding immunity generated by smallpox vaccine may hold lessons for COVID-19 vaccine development. Read More

Manuel Ascano team validates an inhibitor of the cGAS-STING signaling pathway, which is important for cellular innate immunity against bacteria, viruses, and our own damaged DNA. Read More

This is not the Jedi you're thinking of. This Jedi is a receptor that helps clear away dead neurons during development, and its loss changes the activity of dorsal root ganglia neurons, which could have implications for treating chronic pain. Read More

Diffusion MRI may provide a noninvasive approach to assess nerve regeneration and distinguish successful from unsuccessful repairs earlier. Read More

A certain genetic variant, in combination with the use of anti-inflammatory drugs like aspirin and ibuprofen during early pregnancy, may protect women from miscarriage. Read More

Blocking acid reflux-induced production of reactive oxygen compounds may be a useful strategy for preventing DNA damage and decreasing the risk of esophageal cancer. Read More

New findings that reveal complex interactions in esophageal adenocarcinoma could lead to diagnostic, prognostic or therapeutic biomarkers. Read More

With the help of a drug formerly used to treat HIV/AIDS, researchers at Vanderbilt University Medical Center (VUMC) have found a way to make melanoma cells more vulnerable to targeted anti-cancer therapy. Read More

The compound MPLA is an attractive vaccine component, designed to elicit a robust immune response. Read More

In a new study, Vanderbilt pharmacologist Jerod Denton, Ph.D., Ohio State entomologist Peter Piermarini, Ph.D., and colleagues report an experimental molecule that inhibits kidney function in mosquitoes and thus might provide a new way to control the deadliest animal on Earth. Read More

Understanding how mutations affect the structure and function of inhibitory neurotransmitter receptors will shed light on the mechanisms underlying some types of epilepsy. Read More

New findings identify isoketal-modified proteins as a previously unrecognized feature of pulmonary fibrosis and as a potential therapeutic target for this disease. Read More

Certain protein factors have been identified as attractive targets for treating diabetic retinopathy, a major cause of blindness in adults. Read More

Mechanical stress appears to be a critical factor in activating normal tissue-associated fibroblasts to generate cancer-associated fibroblasts. Read More

Vanderbilt researchers have developed tools to probe the role of the essential metal manganese in neurons, and which offer a started point for developing therapeutic agents for manganese-related neurological disorders. Read More