Science Translational Medicine
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Resistance to COVID-19 drug detected in lab study
Vanderbilt research shows that the virus that causes COVID-19 can develop partial resistance to the antiviral drug remdesivir during infection of cultured cells in the laboratory by more than one mechanism. Read MoreMay 10, 2022
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Study provides new insight into how antidepressant drugs work
A study by Vanderbilt researchers sheds light on how current antidepressant drugs work and suggests a new drug target in depression. Read MoreDec 1, 2021
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VUMC team aids development of potential antiviral drug for COVID-19
Researchers at Vanderbilt University Medical Center are playing a key role in the development of a potential new antiviral drug to treat COVID-19. Read MoreApr 6, 2020
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Triple-negative breast cancer drug therapy shows promise
Researchers from Vanderbilt-Ingram Cancer Center (VICC) discovered a role for MYCN in triple-negative breast cancer (TNBC), a particularly aggressive form of the disease, and identified a potential intervention for further clinical investigation. Read MoreMar 12, 2020
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Potential second-line melanoma treatment identified
A study led by Anna Vilgelm, MD, PhD, and Ann Richmond, PhD, has identified a possible second-line treatment for melanoma patients. Read MoreAug 15, 2019
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New imaging approach offers unprecedented views of staph infection
A new integrated imaging approach makes it possible to probe the molecules involved in invasive infections and can be broadly applied to any health or disease state. Read MoreMar 15, 2018
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Drug discovery efforts may lead to new Rett syndrome treatments
Vanderbilt University research-ers have relieved symptoms of Rett syndrome in a mouse model with a small molecule that works like the dimmer switch in an electrical circuit. Read MoreAug 24, 2017
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Breast Cancer Genomic Profiling Reveals Clues to Treatment Resistance
Thanks to advances in treatment, the relative five-year survival rate from all combined subtypes of breast cancer now exceeds 90 percent and yet the disease remains the third leading cause of cancer deaths in the United States after lung and colorectal cancers. Read MoreAug 9, 2017
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Team investigates antiviral that inhibits SARS, MERS
A new antiviral drug candidate inhibits a broad range of coronaviruses, including the SARS and MERS coronaviruses, a multi-institutional team of investigators reports this week in Science Translational Medicine. Read MoreJun 29, 2017
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Scientists create unique disease ‘catalog’ linked to immune system gene variations
A study led by researchers at Vanderbilt University Medical Center (VUMC) and the University of Arizona College of Pharmacy has generated the first comprehensive catalog of diseases in a single population associated with variations in HLA genes that regulate the body's immune system. Read MoreMay 10, 2017
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Study explores how some breast cancers resist treatment
A targeted therapy for triple-negative breast cancer (TNBC), the most aggressive form of breast cancer, has shown potential promise in a recently published study. TNBC is the only type of breast cancer for which there are no currently approved targeted therapies. Read MoreApr 21, 2016
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New nanoparticle enhances success rate of coronary artery bypass grafts
A team of Vanderbilt University Medical Center surgeons and biomedical engineers has developed a nanoparticle delivery system that may significantly improve the success rate of coronary artery bypass grafts. Read MoreJun 18, 2015
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Research at U.S. academic medical centers faces threats to sustainable support
Unstable federal research funding and reductions in health care revenue for academic medical centers threatens to undermine the nation’s biomedical research enterprise, and in turn clinical medicine, which the nation needs now more than ever. Read MoreMay 28, 2015