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Science Translational Medicine Archives

Drug discovery efforts may lead to new Rett syndrome treatments

Aug. 24, 2017—Vanderbilt University research-ers have relieved symptoms of Rett syndrome in a mouse model with a small molecule that works like the dimmer switch in an electrical circuit.

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Health and Medicine Reporter Research


Breast Cancer Genomic Profiling Reveals Clues to Treatment Resistance

Aug. 9, 2017—Thanks to advances in treatment, the relative five-year survival rate from all combined subtypes of breast cancer now exceeds 90 percent and yet the disease remains the third leading cause of cancer deaths in the United States after lung and colorectal cancers.

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Reporter


Team investigates antiviral that inhibits SARS, MERS

Jun. 29, 2017—A new antiviral drug candidate inhibits a broad range of coronaviruses, including the SARS and MERS coronaviruses, a multi-institutional team of investigators reports this week in Science Translational Medicine.

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Health and Medicine Reporter Research


Scientists create unique disease ‘catalog’ linked to immune system gene variations

May. 10, 2017—A study led by researchers at Vanderbilt University Medical Center (VUMC) and the University of Arizona College of Pharmacy has generated the first comprehensive catalog of diseases in a single population associated with variations in HLA genes that regulate the body's immune system.

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Reporter


Study explores how some breast cancers resist treatment

Apr. 21, 2016—A targeted therapy for triple-negative breast cancer (TNBC), the most aggressive form of breast cancer, has shown potential promise in a recently published study. TNBC is the only type of breast cancer for which there are no currently approved targeted therapies.

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Health and Medicine Healthcare Solutions Reporter Research


New nanoparticle enhances success rate of coronary artery bypass grafts

Jun. 18, 2015—A team of Vanderbilt University Medical Center surgeons and biomedical engineers has developed a nanoparticle delivery system that may significantly improve the success rate of coronary artery bypass grafts.

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Health and Medicine Healthcare Solutions Reporter Research Strategic Plan Trans-institutional Programs


Research at U.S. academic medical centers faces threats to sustainable support

May. 28, 2015—Unstable federal research funding and reductions in health care revenue for academic medical centers threatens to undermine the nation’s biomedical research enterprise, and in turn clinical medicine, which the nation needs now more than ever.

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Health and Medicine Reporter Research