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Proceedings of the National Academy of Sciences Archives

Understanding HDL structure

May. 3, 2018—Structural features of newly formed HDL particles will help guide understanding of “good cholesterol” and its function.

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Iron-sulfur “intersection”

Mar. 8, 2018—Vanderbilt researchers have discovered an unanticipated link between sulfur and iron balance, pointing to a genetic basis for iron-deficiency anemia.

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BOLD view of white matter

Jan. 12, 2018—Vanderbilt investigators have discovered that functional MRI detects neural activity in both gray and white matter in the brain, suggesting new ways to investigate diseases such as Alzheimer’s and multiple sclerosis.

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Lighting up iron levels

Jan. 11, 2018—A new probe enables iron imaging in living animals, providing a unique tool for studying iron’s contributions to health and disease.

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Brain lesions and criminal behavior linked to moral decision-making network

Dec. 18, 2017—When brain lesions occur within the brain network responsible for morality and value-based decision-making, they can predispose a person toward criminal behavior, according to new research by Ryan Darby, MD, assistant professor of Neurology at Vanderbilt University Medical Center (VUMC).

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An immune regulator of addiction

Aug. 4, 2017—Although drug addiction is classically studied in a neuron-centric way, Vanderbilt researchers have discovered that the immune system also plays a critical role.

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HDAC3 role in B-cell development

Aug. 3, 2017—The histone deacetylase HDAC3 is required for the maturation of B cells, white blood cells that produce antibodies.

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Immune responses linked to cell’s recycling system

Jul. 20, 2017—Autophagy is the cellular equivalent of trash pickup and recycling — it is a process by which proteins, protein aggregates and damaged cellular organelles are degraded in order to reuse nutrients and promote cellular metabolism.

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Study finds common brain scanning technique maps electrical activity as precisely as more invasive methods

May. 25, 2017—A commonly used brain scanning technique can map electrical activity under the skull as precisely as more invasive methods that rely on probes or electrodes, researchers at Vanderbilt University Medical Center (VUMC) reported this month.

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A new mode of DNA repair

Apr. 14, 2017—Structural details of a protein that removes DNA lesions shed light on fundamental mechanisms of DNA repair.

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New target for chronic infection

Feb. 2, 2017—An enzyme in macrophage immune cells may be a good target for treating chronic infections, Vanderbilt researchers have discovered.

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Research sheds light on how RSV wards off potential vaccines

Oct. 20, 2016—Respiratory syncytial virus (RSV) is the major cause of life-threatening viral pneumonia in infants worldwide, yet despite repeated efforts, scientists have been unable to develop an effective vaccine against it.

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