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Astrocytes and epilepsy

Sep. 9, 2019—A protein with important functions in astrocytes — star-shaped brain support cells — may alter neuronal excitability and contribute to seizure activity, Vanderbilt researchers report.

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How nerves may lose their insulation

Aug. 22, 2019—Vanderbilt’s Bruce Carter and colleagues have discovered how genetic changes in the protein PMP22 may contribute to a disease of peripheral nerves.

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Exploring the brain’s white matter

Mar. 14, 2019—Though neurological activity is generally associated with the brain's gray matter, Muwei Li and colleagues have now measured it in white matter as well.

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Probing the pathology of impaired cognition

Oct. 26, 2018—A new link between a support protein within the brain's white matter and known Alzheimer's biomarkers discovered by Angela Jefferson and colleagues bring researchers a step toward earlier and more precise detection of neuropathology underlying cognitive impairment that may lead to new targeted therapies

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Study links aortic stiffness with lower cerebral blood flow

Aug. 30, 2018—A symptom related to hypertension may play a role in cognitive decline, according to new research by Angela Jefferson.

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New view of the heartbeat

Apr. 6, 2018—Structural views of the proteins that regulate the heartbeat may help improve existing treatments for cardiac arrhythmias.

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Long QT syndrome – revealed

Mar. 12, 2018—Vanderbilt investigators have used sophisticated cell biological and structural techniques to “classify” mutations in potassium channels, studies that could lead to personalized treatment of heart rhythm disorders.

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BOLD view of white matter

Jan. 12, 2018—Vanderbilt investigators have discovered that functional MRI detects neural activity in both gray and white matter in the brain, suggesting new ways to investigate diseases such as Alzheimer’s and multiple sclerosis.

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Impulsivity in Parkinson’s Disease

Oct. 27, 2017—A noninvasive MRI technique may help predict a troubling side effect of common medications for Parkinson’s Disease and improve clinical treatment plans.

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Heat a trigger for seizures

Sep. 6, 2017—Elevated body temperature alone can increase vulnerability to fever-induced seizures, even in the absence of infection or inflammation.

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Predicting brain surgery outcomes

Aug. 18, 2017—Assessing brain functional and structural connectivity in patients with temporal lobe epilepsy may be a useful way to identify the best candidates for surgical treatment.

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Protein structure and epilepsy severity

Nov. 10, 2016—Understanding how mutations affect the structure and function of inhibitory neurotransmitter receptors will shed light on the mechanisms underlying some types of epilepsy.

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