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Protein repairs esophageal DNA damage

Jan. 25, 2012—A protein involved in repairing DNA damage associated with gastric reflux may play a tumor suppressor role in the esophagus and could represent a target for therapies to combat esophageal cancer.

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Alcohol’s molecular mediators

Jan. 23, 2012—Therapeutic agents focusing on the brain region involved in stress-induced relapse may be effective in preventing relapse in patients with alcohol use disorders.

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Studies shed new light on how nitric oxide is produced

Jan. 20, 2012—The discovery of a previously unrecognized and pivotal role of enzyme ASL in nitric oxide production could potentially lead to new therapies for babies with pulmonary hypertension.

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Digestive disease research bolstered by grant renewal

Jan. 20, 2012—The Vanderbilt Digestive Disease Research Center celebrates its 10th anniversary this year with a second five-year renewal of its federal research grant.

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Pumping up the pancreas in pregnancy

Jan. 20, 2012—A strain of mutant mice provide a novel model for studying glucose intolerance and gestational diabetes during pregnancy and suggest that certain molecules may be useful for therapeutic applications.

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Obesity genes linked to uterine cancer

Jan. 20, 2012—In addition to body mass index, genetic markers of obesity may provide value in predicting endometrial cancer risk.

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Clues to flattened faces

Jan. 5, 2012—Mutations in the Jagged1 gene cause Alagille syndrome, an inherited disorder that affects the liver, heart, kidneys and facial structure. Patients with Alagille syndrome often have a prominent forehead, a flattened midface and a prominent chin; some have a cleft palate. To investigate how mutations in Jagged1 cause facial anomalies, Steven Goudy, M.D., and colleagues...

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New schizophrenia drug candidates entering prep for first-in-human testing

Dec. 15, 2011—The progression of new drug candidates for schizophrenia with partner Janssen Pharmaceutica is the latest evidence that a new collaborative model for drug discovery pioneered at Vanderbilt may help identify and develop innovative candidate drugs for treatment of major brain disorders.

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Divvying up chromosomes

Dec. 15, 2011—Protein helps ensure proper division of chromosomes during cell division.

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Virus-linked cancer gets help from host

Dec. 15, 2011—Host cell protein may be a target for strategies to limit spread of virus-induced squamous cell cancers.

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Pathway to colon cancer progression

Dec. 1, 2011—Molecular players involved in colon cancer progression could provide new biomarkers to indicate invasiveness and prognosis.

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Autoimmune drugs don’t boost infection risk: study

Nov. 18, 2011—A Vanderbilt study shows that a class of drugs used to treat autoimmune diseases does not increase the chance of hospitalization for serious infection.

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