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NIH Archives

Pumping up the pancreas in pregnancy

Jan. 20, 2012—A strain of mutant mice provide a novel model for studying glucose intolerance and gestational diabetes during pregnancy and suggest that certain molecules may be useful for therapeutic applications.

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Obesity genes linked to uterine cancer

Jan. 20, 2012—In addition to body mass index, genetic markers of obesity may provide value in predicting endometrial cancer risk.

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Clues to flattened faces

Jan. 5, 2012—Mutations in the Jagged1 gene cause Alagille syndrome, an inherited disorder that affects the liver, heart, kidneys and facial structure. Patients with Alagille syndrome often have a prominent forehead, a flattened midface and a prominent chin; some have a cleft palate. To investigate how mutations in Jagged1 cause facial anomalies, Steven Goudy, M.D., and colleagues...

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New schizophrenia drug candidates entering prep for first-in-human testing

Dec. 15, 2011—The progression of new drug candidates for schizophrenia with partner Janssen Pharmaceutica is the latest evidence that a new collaborative model for drug discovery pioneered at Vanderbilt may help identify and develop innovative candidate drugs for treatment of major brain disorders.

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Divvying up chromosomes

Dec. 15, 2011—Protein helps ensure proper division of chromosomes during cell division.

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Virus-linked cancer gets help from host

Dec. 15, 2011—Host cell protein may be a target for strategies to limit spread of virus-induced squamous cell cancers.

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Pathway to colon cancer progression

Dec. 1, 2011—Molecular players involved in colon cancer progression could provide new biomarkers to indicate invasiveness and prognosis.

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Autoimmune drugs don’t boost infection risk: study

Nov. 18, 2011—A Vanderbilt study shows that a class of drugs used to treat autoimmune diseases does not increase the chance of hospitalization for serious infection.

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Skeletal defects in genetic disorder

Nov. 18, 2011—A new mouse model provides a tool for testing novel therapeutic approaches for neurofibromatosis.

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Let there be light and melatonin

Nov. 4, 2011—Light and the hormone melatonin may play important roles in the developing brain.

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Lung disorder drug regimen found harmful

Oct. 31, 2011—Longtime treatment for IPF ineffective and even dangerous.

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Putting the body back into the mind of schizophrenia

Oct. 31, 2011—A study using a procedure called the rubber hand illusion has found striking new evidence that people experiencing schizophrenia have a weakened sense of body ownership and has produced the first case of a spontaneous, out-of-body experience in the laboratory.

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