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NIDDK

Targeting post-transplant diabetes

Apr. 12, 2012—Targeting diabetes that develops after a stem cell transplant may help moderate graft-vs.-host disease, an adverse effect of the procedure, and improve outcomes.

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Plant compound quells inflammation

Apr. 6, 2012—Berberine, an herbal remedy for diarrhea and intestinal parasites, may be an effective treatment for gastrointestinal inflammatory diseases.

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Obesity turns “good” cholesterol bad

Mar. 21, 2012—Studies offer new insights into how obesity impairs the function of HDL, the “good” cholesterol.

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Colon cancer’s cellular crossroads

Mar. 16, 2012—New information about signaling pathways involved in colorectal cancer could aid in assessing prognosis and identifying new therapeutic targets for the disease.

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Digestive disease research bolstered by grant renewal

Jan. 20, 2012—The Vanderbilt Digestive Disease Research Center celebrates its 10th anniversary this year with a second five-year renewal of its federal research grant.

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Pumping up the pancreas in pregnancy

Jan. 20, 2012—A strain of mutant mice provide a novel model for studying glucose intolerance and gestational diabetes during pregnancy and suggest that certain molecules may be useful for therapeutic applications.

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Clues to flattened faces

Jan. 5, 2012—Mutations in the Jagged1 gene cause Alagille syndrome, an inherited disorder that affects the liver, heart, kidneys and facial structure. Patients with Alagille syndrome often have a prominent forehead, a flattened midface and a prominent chin; some have a cleft palate. To investigate how mutations in Jagged1 cause facial anomalies, Steven Goudy, M.D., and colleagues...

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Meds’ benefits differ in dialysis patients

Jan. 5, 2012—About half of kidney patients will die from heart disease within five years of starting dialysis, yet patients with kidney failure are rarely included in heart disease research. Jorge Gamboa, M.D., T. Alp Ikizler, M.D., and Nancy Brown, M.D., completed a small study that suggests a more personalized approach to selecting medication for heart disease...

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Young stem cells counter kidney aging

Dec. 15, 2011—Young bone marrow cells alleviate aging-related kidney changes in mice.

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Pathway to colon cancer progression

Dec. 1, 2011—Molecular players involved in colon cancer progression could provide new biomarkers to indicate invasiveness and prognosis.

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Protein family key to aging linked to suppressing tumors

Oct. 28, 2011—The list of aging-associated proteins known to be involved in cancer is growing longer, according to research by investigators at Vanderbilt-Ingram Cancer Center and the National Institutes of Health.

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Growth factor boosts beta cells

Oct. 21, 2011—A growth factor may help grow transplantation-quality pancreas cells for treating diabetes.

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