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NIAID

How bugs overcome host defenses

Apr. 12, 2019—Eric Skaar and colleagues have figured out how a common bug responsible for ventilator-associated pneumonia responds when starved of zinc, a metal it needs to survive, which may lead to new therapeutic targets for the dangerous infection.

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Probing H. pylori cancer protein

Feb. 15, 2019—Timothy Cover, john Loh and colleagues have identified how a certain type of mutation influences the risk of premalignant and malignant changes in the stomach.

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Pain relievers a risk for C. diff?

Jan. 17, 2019—David Aronoff and colleagues report an increased risk of the serious gastrointestinal infection C. diff following the use of NSAID pain relievers.

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Parsing diabetic skin infections

Nov. 30, 2018—People with diabetes may be prone to more skin infections due to an overabundance of a compound that controls inflammation in the body.

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New staph virulence factor

Jun. 28, 2018—The new factor, an enzyme involved in host-pathogen interactions, may be a viable target for treating staph infections.

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A “public” target for HIV

Jun. 8, 2018—Common sequences of antibodies against HIV may be key to developing a successful vaccine strategy for the virus.

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Evolution of a deadly virus

May. 23, 2018—Genomic sequences have revealed that Florida is a major source of a mosquito-borne virus that causes disease in horses and humans.

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New target to stop Ebola

May. 21, 2018—A new Vanderbilt study suggests it may be possible to develop antibody therapies or a universal vaccine effective against multiple Ebola virus family members.

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Alphavirus “Achilles heel”

May. 17, 2018—Targeting the protein that mosquito-borne viruses use to enter cells could be a strategy for preventing infection by multiple emerging viruses.

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Putting the brakes on sepsis

May. 9, 2018—An enzyme called PTEN reduces inflammatory signaling and mortality in sepsis, suggesting it may be a good therapeutic target for this life-threatening complication of infection.

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Toxin floats on lipid rafts

Apr. 23, 2018—The bacterium H. pylori is a leading cause of stomach cancer, and Vanderbilt researchers are studying how one of its toxins gets into cells.

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Disease-fighting antibody production

Apr. 20, 2018—New research links nutrient-responsive cellular signaling to the antibody-mediated immune response.

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