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Nature Communications Archives

Study seeks to boost breast tumor immune response

Feb. 8, 2018—Immunotherapy, which harnesses the power of the immune system, is one of the most promising forms of cancer therapy and has been shown to work well against some types of cancer.

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A switch for autoimmunity

Oct. 12, 2017—Vanderbilt investigators have discovered a class of compounds that inhibit a mediator of inflammation and autoimmune disorders, and that could pave the way for development of future therapies.

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Repriming replication roadblocks

Jun. 12, 2017—New findings shed light on how enzymes that replicate DNA skip over mutations that might cause cancer and restart DNA synthesis further away.

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Polarity protein role in cell survival

Apr. 27, 2017—Vanderbilt investigators have identified an unexpected link between cell survival and the polarized delivery of proteins to the surface of mammary epithelial cells.

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Vanderbilt study finds natural chemical helps brain adapt to stress

Mar. 28, 2017—A natural signaling molecule that activates cannabinoid receptors in the brain plays a critical role in stress-resilience — the ability to adapt to repeated and acute exposures to traumatic stress, according to researchers at Vanderbilt University Medical Center.

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VUMC investigators find pathogens work together to infect host

Nov. 3, 2016—Pseudomonas aeruginosa and Staphylococcus aureus — two pathogens that frequently co-infect the lungs of patients with cystic fibrosis — appear to cooperate with each other, Vanderbilt investigators have discovered. When pseudomonas is starved for metal by the host, it shuts down the production of factors that would normally kill staph, promoting a co-infection.

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Study links COPD with increased bacterial invasion

Apr. 28, 2016—Chronic obstructive pulmonary disease (COPD) is a common smoking-related lung illness and the third leading cause of death in the United States. Scientists have long believed that inhaling toxic gases and particles from tobacco smoke causes inflammation of the small airways in the lungs, leading to the development of COPD.

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Melanoma response to immune therapy

Mar. 3, 2016—Melanoma-specific expression of a certain protein identifies tumors that are more responsive to an immune therapy.

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Study finds rerouting bile acids may offer simpler alternative to gastric bypass surgery

Jul. 21, 2015—A new surgical procedure could offer a simpler approach to achieve some of the same weight-loss and metabolic benefits associated with gastric bypass surgery, researchers at VUMC report.

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Study team uses metabolomics to study longevity

Apr. 30, 2015—The keys to longevity have been a source of curiosity and the basis of many research studies for years, yet the mechanisms underlying a person’s ability to live a long life are still not fully understood.

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VU team’s cattle research may yield lung disease clues

Apr. 15, 2015—Vanderbilt University researchers have found a genetic mutation that causes pulmonary hypertension in cattle grazed at high altitude, and which leads to a life-threatening condition called brisket disease.

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VU study creates new road map for cellular activity

Sep. 4, 2014—Human cells are constructed in large part from proteins whose activity can be altered by the incorporation of oxygen in what are known as redox modifications.

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