Oct. 30, 2014—Vanderbilt University investigators have discovered a new molecular mechanism that regulates microtubule dynamics. The unexpected finding, reported in Developmental Cell, has implications for cancer drug discovery.
Dec. 13, 2013—The protein CK1 delays cell division to avoid the generation of defects that drive tumorigenesis.
Jul. 29, 2013—A motor protein that helps drive cell division may be a promising new target for cancer therapeutics.
Dec. 16, 2011—Mitosis, or the separation of chromosomes during cell division, is driven by dynamic interactions between the kinetochore region on chromosomes and string-like structures called microtubules. A number of proteins, including the enzyme Cdk1, regulate these interactions, but it is unclear what kinetochore components such enzymes work upon. Kathy Gould, professor of cell and developmental biology,...