Journal Of Clinical Investigation

A group of Vanderbilt-led investigators has identified a new gene mutation that may explain why some breast cancer patients do not respond to anti-hormone therapy. Read More

Private Property and Government Inaction | Probiotic Could Prevent Obesity | Freedom from Power Cords | Pickiness Doesn’t Always Pay Read More

Researchers at Vanderbilt University, the University of Arizona and Phoenix Children’s Hospital have discovered what triggers a rare but devastating diarrheal disease in newborns that is fatal without intravenous feeding or intestinal transplant. Read More

Engineered bacteria that produce a therapeutic compound in the gut prevent obesity in mice, Vanderbilt University investigators have discovered. Read More

A novel molecular “conversation” regulates kidney fibrosis – the final result of end-stage chronic kidney disease – suggesting new treatment options for this currently irreversible process. Read More

Researchers at Vanderbilt University have identified a potential new drug target in subtypes of lung cancer that are difficult to treat. Read More

One of the most formidable weapons in a cancer’s arsenal is the ability to spread to other organs. Read More

A compound identified at Vanderbilt has therapeutic potential in protecting the kidney filter barrier. Read More

Rebecca Cook, Ph.D., assistant professor of Cancer Biology, has spent her life trying to understand what makes things grow, from seedlings in soil to tumor cells in the body. Read More

Researchers at the Vanderbilt Heart and Vascular Institute and Massachusetts General Hospital have identified a biomarker that can predict diabetes risk up to 10 years before onset of the disease. Read More

Clinical pharmacologist Jens Titze, M.D., and his colleagues have identified a new cast of cells and molecules that function in the skin to control sodium balance and blood pressure. Read More

Vanderbilt University investigators have developed a new strategy for identifying the “bits” of a pathogen that spark a protective immune response. Read More

Many patients with triple-negative breast cancer (TNBC) have recurrence of their disease after an initial response to chemotherapy because the cancer cells have become resistant to treatment. TNBC has a lower survival rate because of this pattern of resistance and there are no targeted agents to treat this form of breast cancer. Read More

The HIF oxygen-sensing pathway and its responses to low oxygen may be targeted for treatments of anemia and disorders of iron balance. Read More

The kidney can mediate its own repair through proliferation of resident immune system cells. Read More

Viruses that cause acute respiratory infections — such as human metapneumovirus (HMPV) and flu — impair a set of immune system cells that should clear the virus from the lungs. Now, Vanderbilt University investigators have discovered the signaling pathway that disables these immune cells. Read More

A protein critical in heart development may also play a part in colon cancer progression. Read More