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infection Archives

Lighting up iron levels

Jan. 11, 2018—A new probe enables iron imaging in living animals, providing a unique tool for studying iron’s contributions to health and disease.

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Excess dietary manganese increases risk of staph infection in heart

Sep. 21, 2017—Too much dietary manganese — an essential trace mineral found in leafy green vegetables, fruits and nuts — promotes infection of the heart by the bacterium Staphylococcus aureus (“staph”).

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Predicting the infection response

Apr. 19, 2017—Vanderbilt investigators are probing the response to a bacterial toxin as a clinical assessment of immune function.

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Immune defenses in asthma

Apr. 5, 2016—Vanderbilt researchers show that a certain factor negatively impacts the first-line responder cells in the lungs, providing one explanation for why patients with asthma are at greater risk for invasive bacterial disease.

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Eye of a cytokine storm

Mar. 9, 2016—A new animal model can be used to “dissect” the inflammatory response to infection.

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Study links opioids, infection risk for patients with rheumatoid arthritis

Nov. 19, 2015—Use of opioid analgesics is associated with an increased risk of hospitalization for serious infections among patients with rheumatoid arthritis, according to a Vanderbilt study published in Arthritis & Rheumatology.

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Detect and defend against pathogens

Nov. 4, 2015—Understanding factors, such as the receptor TLR9, that detect and defend against pathogens may lead to therapeutic approaches that promote an effective immune response to treat infections.

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Study identifies C. diff toxin receptor, suggests new treatment approaches

Jun. 4, 2015—Vanderbilt University investigators have identified a cellular receptor for a toxin from Clostridium difficile (“C. diff”) — the leading cause of hospital-acquired diarrhea in the United States.

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Preventing early pregnancy complications

May. 20, 2015—The enzyme alkaline phosphatase may provide a new therapeutic option for women at high risk of pregnancy complications due to bacterial toxin exposure.

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Stuffed animals bring bacteria to OR

Apr. 17, 2015—Stuffed animals that pediatric patients bring to the operating room are a reservoir of bacteria that can be effectively sterilized in a household washer/dryer the day before surgery.

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Bacterial secretion machinery: 3-D view

Dec. 11, 2014—New structural findings reveal how "gatekeeper" proteins participate in the secretion systems bacteria use to infect host cells.

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Peptide quells “genomic storm”

Oct. 28, 2014—A cell-penetrating peptide developed at Vanderbilt blocks the signaling pathways that lead to lethal shock caused by bacterial infection.

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