GWAS
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New tool to probe genetic mechanisms of disease
Vanderbilt Genetics Institute investigators have added a new method to the computational genetics toolbox. Their approach, described in the journal Nature Genetics, integrates vast genomics datasets to predict gene expression and facilitate discovery of genetic mechanisms underlying human diseases. Read MoreOct 22, 2020
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Genes spell penicillin allergy risk
Studies using large DNA biobanks revealed genetic variants associated with penicillin allergy, the most common type of drug-induced allergic reaction. Read MoreOct 1, 2020
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Potential prostate cancer biomarkers
An analysis of more than 140,000 people of European ancestry has identified blood protein biomarkers associated with prostate cancer risk. Read MoreSep 19, 2019
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Cancer susceptibility genes
Gene variants associated with cancer risk appear to contribute to carcinogenesis by regulating target genes that in turn promote the generation of mutations. Read MoreAug 26, 2019
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Shared genetics may shape treatment options for certain brain disorders
Symptoms of schizophrenia and bipolar disorder, including psychosis, depression and manic behavior, have both shared and distinguishing genetic factors, an international consortium led by researchers from Vanderbilt University and Virginia Commonwealth University is reporting. Read MoreJun 14, 2018
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Probing the genetics of autoimmunity
Vanderbilt researchers have found that non-coding regions of the genome appear to contribute to the risk of autoimmune diseases and may represent attractive therapeutic targets. Read MoreJul 21, 2017
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Genetics of lung cancer survival
Vanderbilt investigators have conducted a first-of-its-kind genome-wide association study of lung cancer survival in African-Americans. Read MoreJun 29, 2017
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VU study reveals shared pathways in psychiatric disorders
Schizophrenia and bipolar disorder share common genetic underpinnings. Vanderbilt researchers combined high-resolution gene expression studies with gene association data to reveal signaling pathways linked to schizophrenia and bipolar disorder. Read MoreSep 18, 2014
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Pioneers of Discovery: Computer science drives Capra’s biomedical research
Tony Capra, Ph.D., is a new assistant professor of Biomedical Informatics and investigator in the Center for Human Genetics Research at Vanderbilt. His goal is to use the tools of computer science to address problems in genetics, evolution and biomedicine. Read MoreOct 3, 2013
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Gene interactions and cavities
Vanderbilt researchers used existing genome-wide association study datasets to identify gene interactions that contribute to tooth decay. Read MoreSep 30, 2013
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Tool finds connections in genome data
A new analytical tool points to genes that act together to increase disease risk. Read MoreFeb 8, 2012
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Study applies random genotype sets to new disease
A new study in the American Journal of Human Genetics, led by Vanderbilt researchers Josh Denny, M.D., M.S., and Dana Crawford, Ph.D., takes random volumes of human genotypes and matches them with data siphoned from de-identified medical records and sheds new light on the genetic basis of the common… Read MoreJan 5, 2012