Genetic Variant
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Gene variant linked to unnecessary bone marrow biopsies in African Americans
A gene variant that lowers white blood cell levels and is common in individuals with African ancestry contributes to unnecessary bone marrow biopsies, according to a study published June 28 in JAMA Internal Medicine. The findings, led by investigators at VUMC, are an example of how using genetic data could reduce a health disparity. Read MoreJun 28, 2021
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Gene variant and glucose metabolism
Genetic variation that impacts glucose- and insulin-related signaling affects responses to type 2 diabetes treatments and warrants further study. Read MoreFeb 18, 2021
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Tailoring treatment for heart defect
By defining the clinical and genetic factors that predict treatment response, Vanderbilt investigators aim to personalize therapy for a common heart complication in preterm infants. Read MoreSep 23, 2019
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Cancer susceptibility genes
Gene variants associated with cancer risk appear to contribute to carcinogenesis by regulating target genes that in turn promote the generation of mutations. Read MoreAug 26, 2019
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Shared genetics may shape treatment options for certain brain disorders
Symptoms of schizophrenia and bipolar disorder, including psychosis, depression and manic behavior, have both shared and distinguishing genetic factors, an international consortium led by researchers from Vanderbilt University and Virginia Commonwealth University is reporting. Read MoreJun 14, 2018
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New breast cancer targets
A special genetic analysis has revealed candidate genes associated with increased risk of breast cancer. Read MoreMay 4, 2018
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Calcium intake and colorectal cancer
Calcium intake appears to protect against colorectal cancer in individuals with certain gene variants, Vanderbilt researchers have discovered. Read MoreOct 18, 2017
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NSAIDs, genetics and miscarriage
A certain genetic variant, in combination with the use of anti-inflammatory drugs like aspirin and ibuprofen during early pregnancy, may protect women from miscarriage. Read MoreSep 20, 2017
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Culprits in genetic epilepsies
Genetic variation in GABA-A receptors confers risk for inherited forms of epilepsy. Read MoreOct 11, 2016
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New technique helps spot atrial fibrillation genetic variations
A technique called whole-exome sequencing (WES) has been used for the first time at Vanderbilt University to identify new genetic variations associated with a common disease — a heart rhythm abnormality called atrial fibrillation (AF). Read MoreMay 8, 2014
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Potential mechanism for myeloma drug’s variable toxicity
A genetic variant is associated with toxicity of the chemotherapy drug melphalan, and could guide individualized dosing for the medication. Read MoreApr 30, 2014
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A pain in the … genes
Vanderbilt researchers have discovered that variation in the gene encoding the potassium channel GIRK1 plays a role in modulating human pain perception. Read MoreJan 10, 2014
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Gene database to aid disease research
A new catalog of human genetic data may help researchers uncover the genetic roots of disease and enable the ultimate realization of personalized medicine. Read MoreJun 19, 2012
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New clue to ADHD
A rare genetic change adds support to the idea that altered dopamine signaling is a key risk factor for ADHD. Read MoreMay 15, 2012