F Guengerich
-
Steroid binding to metabolic enzyme
Understanding how a steroid-metabolizing enzyme binds to its substrates may aid in designing drugs to treat sexual dysfunction as well as prostate cancer. Read MoreJun 12, 2019
-
Altered metabolism and disease
Vanderbilt researchers report a structure of a human metabolic enzyme bound to its substrate 17alpha-hydroxyprogesterone. Read MoreJul 25, 2017
-
Faulty building blocks in DNA
An enzyme that builds DNA is able to insert the wrong building blocks, which could generate mutations. Read MoreJan 22, 2016
-
Rational design of novel antifungals
Structural and molecular details of an anti-fungal target's interaction with inhibitors suggest ways to design better treatments for fungal infections. Read MoreOct 7, 2015
-
How the cell makes morphine
Vanderbilt investigators have discovered how mammals, including humans, produce the painkiller morphine. Read MoreAug 25, 2015
-
Bypassing DNA damage
Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage. Read MoreMay 9, 2014
-
Carcinogenic chemicals cramp DNA
Researchers have determined how a DNA lesion caused by exposure to chemicals may spark cancer formation. Read MoreNov 21, 2012
-
An orphan enzyme’s purpose
“Orphan” enzyme may play role in cancer growth, new research suggests. Read MoreOct 4, 2012
-
DNA: From modification to mutation
Understanding how an environmental hazard damages DNA may shed light on processes of tumor formation. Read MoreJun 8, 2012