Extracellular Matrix

The rigidity of the extracellular matrix that surrounds cells impacts the contractile and invasive properties of head and neck cancer cells. Read More

A previously unrecognized role for a cell surface receptor may open new therapeutic options for the treatment of fibrotic diseases. Read More

The rigidity of the microenvironment around cancer cells drives invasive behavior through distinct ROCK signaling pathways, which could guide the development of specific anti-invasive therapies. Read More

The rigidity of the bone extracellular matrix increases the ability of tumor cells to destroy bone, suggesting new targets for anticancer drug development. Read More

A protein that degrades the “matrix” between cells participates in the development of lung metastases from primary breast cancer in mouse models and may be a good target for breast cancer treatment. Read More

The contractile machinery inside tumor cells increases invasive properties, suggesting it might be a good target to inhibit cancer cell spread. Read More

The extracellular matrix that surrounds cells plays a role in the development of insulin resistance. Read More

A component of the extracellular matrix that surrounds cells plays a role in insulin resistance and may be a good therapeutic target. Read More

Ela Knapik, associate professor of medicine, and colleagues are using zebrafish to explore the molecular and cellular mechanisms that cause birth defects of the face and skeleton. Read More