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EGFR Archives

Researchers find novel mechanism of resistance to anti-cancer drugs

Oct. 17, 2017—Vanderbilt investigators have discovered a novel non-genetic cause of resistance to the targeted anti-cancer therapy cetuximab. Their findings, reported this week in Nature Medicine, suggest a strategy for overcoming this resistance.

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New tools to combat kidney fibrosis

Oct. 13, 2017—Vanderbilt investigators have developed a new mouse model of kidney fibrosis, which provides a platform for identifying new targets and treatment strategies.

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Glowing receptors help find and track cancerous growth

May. 18, 2017—Under the microscope, they sparkle like emeralds, these molecules that may hold a key to understanding — and stopping — cancerous growth.

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New target for colorectal cancer

Mar. 17, 2017—Vanderbilt investigators have discovered that activated epidermal growth factor receptor may be a target for therapies to prevent colorectal cancer development.

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EGF receptor found to regulate macrophage inflammation in gut

Oct. 13, 2016—Researchers at Vanderbilt University School of Medicine have uncovered a link between epidermal growth factor receptor (EGFR) signaling and the inflammatory response to bacterial infection in the gastrointestinal tract.

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Drug combos for glioblastoma

May. 3, 2016—Vanderbilt researchers have discovered that activation of a certain signaling pathway protects brain cancers from targeted therapies, suggesting that using therapeutics that block both pathways may be a promising treatment.

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Bad “traffic” linked to cancer

Sep. 3, 2015—Understanding how signaling molecules are transported within and out of the cell may help to uncover the causes of certain cancers.

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Probing mutant EGF receptor regulation

Oct. 10, 2013—Understanding the regulation of mutant EGF receptors commonly found in lung cancers could lead to new targeted therapies.

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Plant compound stops colon cancer cells

Mar. 29, 2013—Berberine, an herbal remedy for diarrhea and intestinal parasites, may be useful in colon cancer therapy.

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HER2 may impact lung cancer therapy

Sep. 21, 2012—A protein associated with aggressive breast cancers may also influence resistance of lung cancer to targeted therapies.

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