Ege Kavalali

For centuries, the human brain has intrigued scientists and philosophers alike. It stores our memories and shapes our behavior—the center of learning, emotion and identity. Yet even after decades of research, much about how the brain works remains a mystery. “People have been fascinated with questions of how you learn and who you are—philosophical questions that all come back to processes in the brain,” says Lisa Monteggia, Lee E. Limbird Professor in Pharmacology and the Barlow Family Director of the Vanderbilt Brain Institute. Now neuroscience is at a watershed moment, with new tools poised to dramatically expand understanding of the central nervous system.   Read More

Gentle caress, searing burn, jolting shock. All these are possible with the elemental power of touch. Read how Shan Meltzer studies touch from the cellular level through the nervous system to the brain, to find better ways to treat pain and physical injuries. Read More

Shan Meltzer has been awarded a prestigious Edward Mallinckrodt, Jr. Foundation Award to advance her pioneering research that seeks to determine how the body’s sensory circuits form and function. Her work seeks to answer a fundamental question in neuroscience: how do the brain and spinal cord organize their intricate networks to perform such a wide range of functions? Read More

In a new study published in Science, Lisa Monteggia’s and Ege Kavalali’s labs show that it is feasible to substantially extend the efficacy of a single dose of ketamine from its current duration of up to a week to a longer period of up to two months. Read More

The laboratory of Ege Kavalali, professor and chair of the Department of Pharmacology, published a new paper in Nature Communications that determined that liquid-liquid phase separation plays a key role within the nanostructure of synapses, and that its disruption affects evoked but not spontaneous neurotransmission. Read More

Ege Kavalali and Heidi Hamm collaborated to discover a signaling pathway for how spontaneous release of neurotransmitters can be selectively regulated without disrupting evoked action potentials. Read More

Ege T. Kavalali, PhD, professor and acting chair of the Department of Pharmacology in the Vanderbilt University School of Medicine, has been elected a recipient of a prestigious Humboldt Research Award by the Alexander von Humboldt Foundation of Germany. Read More