DNA Replication

  • Concept of DNA molecule composed of computer imagery like numbers

    Researchers discover that protein switches functions to regulate DNA replication

    Vanderbilt biochemists have discovered that the protein RADX has different biological effects at sites of DNA synthesis, depending on the cellular conditions — even though it works the same way in both stressed and unstressed cells. Read More

    Jul 22, 2021

  • DNA helix with a piece cut off and set to the side

    Probing DNA damage repair

    After discovering a new mechanism for DNA damage repair last year, Vanderbilt biochemists now provide direct evidence for how it works. Read More

    Jun 18, 2020

  • DNA code

    Completing DNA synthesis

    James Dewar and colleagues have identified a role for the enzyme topoisomerase II in reducing replication errors during the final stage of DNA synthesis. Read More

    Oct 21, 2019

  • 3D render DNA strands

    A catalog of DNA replication proteins

    Vanderbilt scientists have identified 593 proteins that are enriched at sites of DNA duplication and chromatin packaging of newly synthesized DNA. Read More

    Oct 3, 2019

  • Vanderbilt University

    Repriming replication roadblocks

    New findings shed light on how enzymes that replicate DNA skip over mutations that might cause cancer and restart DNA synthesis further away. Read More

    Jun 12, 2017

  • Vanderbilt University

    Team identifies ‘switch’ involved in DNA replication  

    DNA replication is an extraordinarily complex multi-step process that makes copies of the body’s genetic blueprint. It is necessary for growth and essential to life. Now researchers at the California Institute of Technology (Caltech) and Vanderbilt University have found evidence that one of those steps may involve the telephone-like transmission of electrical signals regulated by a chemical “switch.” Read More

    Feb 23, 2017

  • Vanderbilt University

    DNA damage response protein

    Vanderbilt researchers have determined that a previously uncharacterized protein responds to DNA replication stress and has an essential role in maintaining the integrity of the genome. Read More

    Oct 21, 2016

  • Vanderbilt University

    Mechanism of a DNA repair protein

    Vanderbilt investigators have discovered details about the mechanism of an important DNA repair protein that maintains genome stability. Read More

    Apr 15, 2016

  • Vanderbilt University

    Copying chromosome caps

    Telomeres – the caps on the end of chromosomes – are a source of stress for a particular protein involved in copying DNA, a new study reports. Read More

    Jan 8, 2016

  • DNA sequence visualization

    Study helps clarify components of DNA ‘copy machine’

    Vanderbilt investigators have generated a “parts list” for the molecular machinery that duplicates DNA each time a cell divides. The research has implications for cancer therapies that target components of this machinery. Read More

    Nov 12, 2015

  • DNA sequence visualization

    Study reveals how protein helps cells tolerate DNA damage

    Vanderbilt and Stanford investigators have discovered how a protein that's part of the DNA replication "machinery" helps cells tolerate DNA damage. Read More

    Jul 16, 2015

  • Vanderbilt University

    Repair protein’s DNA recognition motif

    Insights into the workings of DNA damage response proteins such as SMARCAL1 could suggest new ways to improve genome integrity and prevent cancer. Read More

    May 23, 2014

  • Vanderbilt University

    Bypassing DNA damage

    Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage. Read More

    May 9, 2014

  • Vanderbilt University

    VU study sheds new light on DNA replication

    David Cortez, Ph.D., and his Vanderbilt colleagues report new findings that shed light on fundamental processes involved in DNA replication and have implications for cancer therapies that target these processes. Read More

    Nov 7, 2013

  • Vanderbilt University

    New view of DNA processing ‘hub’

    Structural studies reveal a new framework for understanding a central player in DNA processing. Read More

    Jan 23, 2013

  • Vanderbilt University

    iPOND method goes fishing for proteins

    A new tool will allow researchers to identify proteins involved in DNA replication and damage repair, processes that go awry in cancer. Read More

    Mar 19, 2012

  • Vaughan Jones

    Beyond knot theory

    I’ve always been fascinated, and occasionally frustrated, by the tendency of string, yarn, rope and wire – any thing that is long, thin and flexible – to knot and tangle. Fields Medal winner Vaughan F.R. Jones Clearly, I’m not the only one. Mathematicians have been studying knots… Read More

    Apr 14, 2011

  • Vaughan Jones

    Fields Medalist joins Vanderbilt faculty

    One of the world’s foremost mathematicians, Vaughan F. R. Jones, has accepted a position as distinguished professor of mathematics at Vanderbilt University beginning in the fall of 2011. Read More

    Apr 6, 2011