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DNA damage Archives

Mitochondrial mutations and disease

Feb. 22, 2018—New findings suggest that oxidative stress damages mitochondrial DNA, and they link this damage to a disease state.

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DNA damage repair: molecular insights

Dec. 5, 2017—Structural details about a protein involved in the repair of damaged DNA provide insight into xeroderma pigmentosum disorders, which are characterized by increased risk for skin cancer.

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Repriming replication roadblocks

Jun. 12, 2017—New findings shed light on how enzymes that replicate DNA skip over mutations that might cause cancer and restart DNA synthesis further away.

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DNA damage response protein

Oct. 21, 2016—Vanderbilt researchers have determined that a previously uncharacterized protein responds to DNA replication stress and has an essential role in maintaining the integrity of the genome.

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Mechanism of a DNA repair protein

Apr. 15, 2016—Vanderbilt investigators have discovered details about the mechanism of an important DNA repair protein that maintains genome stability.

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Copying chromosome caps

Jan. 8, 2016—Telomeres – the caps on the end of chromosomes – are a source of stress for a particular protein involved in copying DNA, a new study reports.

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Study reveals how protein helps cells tolerate DNA damage

Jul. 16, 2015—Vanderbilt and Stanford investigators have discovered how a protein that's part of the DNA replication "machinery" helps cells tolerate DNA damage.

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Repair protein’s DNA recognition motif

May. 23, 2014—Insights into the workings of DNA damage response proteins such as SMARCAL1 could suggest new ways to improve genome integrity and prevent cancer.

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Bypassing DNA damage

May. 9, 2014—Studies of a human polymerase that replicates DNA have provided a complete kinetic and structural framework for understanding how the enzyme accurately bypasses DNA damage.

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Probing roles of a cell death protein

Jul. 17, 2013—Vanderbilt researchers have discovered new roles for a protein involved in cell death processes that are activated to prevent tumor-causing DNA mutations.

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A drug combo for ovarian cancer

Dec. 24, 2012—Combining another drug with platinum-based chemotherapies may be more effective against ovarian cancer.

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Carcinogenic chemicals cramp DNA

Nov. 21, 2012—Researchers have determined how a DNA lesion caused by exposure to chemicals may spark cancer formation.

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