Division Of Clinical Pharmacology

A Vanderbilt study found that prostate cancer polygenic risk score has limited utility for enhancing prostate cancer screening. Read More

Vanderbilt University Medical Center researchers have made a fundamental discovery about how the heart compensates for genetic variations that otherwise could trigger abnormal and potentially fatal heart rhythms. Read More

Vanderbilt researchers used genetics tools and biobanks with linked electronic health records to explore the associations between statins and noncardiovascular diseases. Read More

Heat therapy could offer a novel nonpharmacologic approach for treating the overnight hypertension that affects patients with autonomic failure. Read More

Vanderbilt researchers have developed a response score using genetic and clinical information to aid prescribing of the widely used pain medication codeine. Read More

Insight into the pathophysiology of an enigmatic and debilitating disease suggests new treatment approaches. Read More

Oxidative stress and toxic products called isolevuglandins in mitochondria play a role in endothelial dysfunction and hypertension — and getting rid of them with a special “scavenger” molecule has therapeutic potential. Read More

Excess dietary salt activates immune cells to induce inflammation and hypertension, supporting current recommendations for low sodium consumption. Read More

Vanderbilt University Medical Center investigators have used high-throughput robotic technology to rapidly study and classify variations in a gene linked to heart rhythm disorders and cardiac conditions. Read More

Photo by John Russell Dr. John Oates, an internationally known physician at Vanderbilt University School of Medicine and a founder of the discipline of clinical pharmacology, died July 30 in Nashville after a short illness. He was 87. The Thomas F. Frist Sr. Professor of Medicine, he founded the Division… Read More

Vanderbilt researchers have discovered that a protein called SGK1 in immune cells is activated by sodium, leading to the development of salt-sensitive hypertension. Read More

Meena Madhur, MD, PhD, has received a Presidential Early Career Award for Scientists and Engineers. Read More

“Big data” can help reverse the alarming decline in life expectancy in the United States — if universities and academic medical centers take the lead, former U.S. Food and Drug Administrator Robert Califf, MD, told a Vanderbilt audience last week. Read More

John Oates, M.D., a pioneering clinical pharmacologist at Vanderbilt University Medical Center (VUMC), has been awarded a one-year, $20,000 grant from the Brain Aneurysm Foundation to support studies of the stroke-reducing potential of acetaminophen. Read More

New findings could explain the link between chronic stress and reduced survival in women diagnosed with breast cancer, and could lead to new strategies to improve treatment outcomes. Read More

Interventions that increase circulating levels of compounds called EETs may improve insulin sensitivity and treat hypertension. Read More

Costantino Iadecola, M.D., an expert in the molecular pathology of ischemic brain injury and neurodegeneration at Weill Cornell Medical College in New York, will present the 10th annual Meredith S. and John A. Oates Lectureship in Clinical Pharmacology on Nov. 3. Read More

Mary Relling, Pharm.D., chair of the Department of Pharmaceutical Sciences at St. Jude Children’s Research Hospital in Memphis, will deliver this year’s Grant R. Wilkinson Distinguished Lecture in Clinical Pharmacology on Thursday, April 9. Read More

The evidence is increasing: the immune system and inflammation are key contributors to high blood pressure. Read More

Patients with orthostatic intolerance – problems when standing – have cognitive changes, even when seated, compared to healthy individuals. Read More