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Department of Cell and Developmental Biology Archives

Macara named ‘Pink Tie Guy’ for Komen breast cancer research

Jan. 11, 2018—Ian Macara, PhD, Louise B. McGavock Professor and Chair of Cell and Developmental Biology and co-leader of the Signal Transduction and Chemical Biology Research Program at Vanderbilt-Ingram Cancer Center (VICC), has been named one of the Pink Tie Guys for the Susan G. Komen Central Tennessee organization.

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Research sheds light on how microtubules are assembled

Jan. 4, 2018—Microtubules are the “railroad tracks” essential for moving intracellular “freight” around in the cell. They’re also part of the spindle that pulls the two centrosomes apart during cell division.

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Lineage tracing in the gut

Nov. 30, 2017—Vanderbilt investigators have developed an algorithm to classify cell types from experimental data, making it possible to understand how organs develop.

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Advanced imaging tools reveal architecture of cell division machinery

Nov. 9, 2017—Using super-resolution microscopy tools in the Nikon Center of Excellence, Vanderbilt investigators have determined the molecular architecture of the contractile ring machinery that functions during cell division — a process that is essential for life.

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Gut response to fluid flow

Oct. 26, 2017—Vanderbilt researchers have discovered that microvilli – finger-like projections from cells in the intestine – respond to the shear stress of fluid flow to drive a cellular pathway that regulates nutrient balance.

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Researchers find novel mechanism of resistance to anti-cancer drugs

Oct. 17, 2017—Vanderbilt investigators have discovered a novel non-genetic cause of resistance to the targeted anti-cancer therapy cetuximab. Their findings, reported this week in Nature Medicine, suggest a strategy for overcoming this resistance.

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Goal of new tissue-chip research is to assess efficacy of novel epilepsy drugs

Sep. 20, 2017—An interdisciplinary team of Vanderbilt University researchers has received a two-year, $2-million federal grant to develop an “organ-on-chip” model for two genetic forms of epilepsy.

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Epigenetics expert Allis set for Sept. 7 Discovery Lecture

Aug. 31, 2017—Internationally known epigeneticist C. David Allis, Ph.D., will deliver the first Flexner Discovery Lecture of the academic year at 4 p.m. Thursday, Sept. 7, in room 208 Light Hall.

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Discovery sheds light on protein key to nerve cells’ myelin sheath

Aug. 17, 2017—Genetic mutations in PMP22 (peripheral myelin protein 22) cause a variety of peripheral neuropathies, underscoring the importance of the protein to a healthy peripheral nervous system. But the precise function of PMP22, a major component of the myelin sheath that surrounds and insulates peripheral nerve cell axons, has been unclear.

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NOTCH1 role in heart development

Jul. 3, 2017—The identification of a genetic culprit for hypoplastic left heart syndrome could lead to new treatments for the condition.

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Class of 2017: Jarrod Shilts makes biological discoveries and collaborates across disciplines

May. 3, 2017—When Boston native Jarrod Shilts arrived at Vanderbilt, he brought with him a strong interest in synthetic biology—a discipline devoted to designing and creating biological molecules that don’t exist in the natural world and using them to redesign existing biological systems.

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A molecular clue to longevity

Mar. 31, 2017—In budding yeast, accumulation of a certain type of RNA in the nucleus increased life span, offering a new clue to longevity.

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