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Department of Cell and Developmental Biology Archives

SMAD4 clue to colon cancer

Jul. 5, 2018—Chronic inflammation is a predisposing condition for colorectal cancer, the third leading cause of cancer-related deaths in the United States. Anna Means, Ph.D., and colleagues have now linked inflammation-driven carcinogenesis in the colon to loss of an important signaling protein called SMAD4.

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Looking beyond the ‘magic bullet’ approach to drug discovery

May. 1, 2018—Vanderbilt scientists have developed a new process that can rapidly and inexpensively identify personalized cancer drugs derived from nature.

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Toxin floats on lipid rafts

Apr. 23, 2018—The bacterium H. pylori is a leading cause of stomach cancer, and Vanderbilt researchers are studying how one of its toxins gets into cells.

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Department of Cell and Developmental Biology hosts Cell Dynamics Symposium May 24–25

Apr. 20, 2018—The Department of Cell and Developmental Biology within the Vanderbilt University School of Medicine hosts its second Cell Dynamics Symposium May 24–25 in Wilson Hall.

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MIT’s Orr-Weaver wraps up spring Discovery Lecture series April 26

Apr. 19, 2018—The spring Flexner Discovery Lecture series wraps up on Thursday, April 26, with a presentation by Terry Orr-Weaver, PhD, professor of Biology at the Massachusetts Institute of Technology.

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Study tracks protein’s role in stem cell function

Mar. 22, 2018—MCL-1 is a member of the BCL-2 family of proteins important for blocking apoptosis, or programmed cell death. Many types of cancer cells escape the body’s effort to kill them by overexpressing MCL-1.

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Structure of a stem cell niche

Feb. 28, 2018—Understanding the specialized environment where stem cells reside is important for developing stem-cell based regenerative therapies.

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Cell skeleton and the brush border

Jan. 31, 2018—Vanderbilt researchers have discovered a role for microtubules — part of the cellular “skeleton” — in organizing the unique sidedness of the epithelial cells that line organs like the intestines.

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Macara named ‘Pink Tie Guy’ for Komen breast cancer research

Jan. 11, 2018—Ian Macara, PhD, Louise B. McGavock Professor and Chair of Cell and Developmental Biology and co-leader of the Signal Transduction and Chemical Biology Research Program at Vanderbilt-Ingram Cancer Center (VICC), has been named one of the Pink Tie Guys for the Susan G. Komen Central Tennessee organization.

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Research sheds light on how microtubules are assembled

Jan. 4, 2018—Microtubules are the “railroad tracks” essential for moving intracellular “freight” around in the cell. They’re also part of the spindle that pulls the two centrosomes apart during cell division.

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Lineage tracing in the gut

Nov. 30, 2017—Vanderbilt investigators have developed an algorithm to classify cell types from experimental data, making it possible to understand how organs develop.

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Advanced imaging tools reveal architecture of cell division machinery

Nov. 9, 2017—Using super-resolution microscopy tools in the Nikon Center of Excellence, Vanderbilt investigators have determined the molecular architecture of the contractile ring machinery that functions during cell division — a process that is essential for life.

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