Colorectal Cancer
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Colorectal cancer ‘cartography’ reveals an avenue to improved immunotherapy
Vanderbilt University Medical Center researchers have discovered why most colorectal tumors escape detection and destruction by the body’s immune system. Read MoreDec 8, 2023
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Holowatyj receives National Cancer Institute MERIT Award
Vanderbilt's Andreana Holowatyj, PhD, MSCI, has received the National Cancer Institute’s Method to Extend Research in Time Award to support her ongoing investigation into how early-onset colorectal cancer and its treatments impact reproductive health. Read MoreJul 19, 2023
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Early-onset CRC germline genetic differences identified by race, ethnicity
A Vanderbilt study that delved into genetic predisposition for early-onset colorectal cancer by race and ethnicity has identified differing germline risk variants. Read MoreJun 15, 2023
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Better adenoma detection
Fluorescent nanoparticles clearly identified colonic adenomas — precursors to colorectal cancer — in mice, and the formulation should translate to clinical use in humans. Read MoreMay 4, 2023
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Lee named 2022 Innovation Fund investigator by The Pew Charitable Trusts
Ethan Lee, professor of cell and developmental biology and pharmacology, has been named a 2022 Innovation Fund investigator by The Pew Charitable Trusts. Read MoreSep 27, 2022
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Colon cancer researchers awarded NCI grant for study of early lesions
Vanderbilt researchers are studying precancerous lesions and early cancers in the colon, with the goal of developing new ways to prevent colorectal cancer, the nation’s second leading cancer killer. Read MoreSep 22, 2022
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C. difficile may contribute to colorectal cancer: study
A Vanderbilt study found that the bacterium Clostridioides difficile (C. difficile) may be a previously unrecognized contributor to colorectal cancer. Read MoreJul 28, 2022
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Researchers find potential new target against colorectal cancer
Researchers at Vanderbilt University Medical Center have discovered a potential new target in the fight against colorectal cancer, the nation’s third most common malignancy and, next to lung cancer, the second leading cancer killer. Read MoreJul 21, 2022
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Diet and colorectal cancer risk
Higher dietary intake of antioxidant compounds found in fruits, vegetables, teas and spices was associated with lower risk of colorectal cancer, and intake was lower among Black participants, potentially contributing to colorectal cancer health disparities. Read MoreFeb 14, 2022
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CRISPR screen identifies new anti-inflammatory drug target
A novel CRISPR screen developed by Vanderbilt researchers identified a promising new target for anti-inflammatory therapeutics. Read MoreNov 11, 2021
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People at high genetic risk for colorectal cancer benefit more from lifestyle changes
People with a high polygenic risk score for colorectal cancer could benefit more at preventing the disease by leading healthy lifestyles than those at lower genetic risk, according to a study by Vanderbilt researchers published in the April issue of The American Journal of Clinical Nutrition. Read MoreMay 13, 2021
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Vanderbilt experts discuss colorectal cancer research progress in virtual event
In recognition of Colorectal Cancer Awareness Month, the School of Medicine Basic Sciences will host a panel discussion, "On the Cutting Edge: Research Toward a Cure for Colorectal Cancer,” on Tuesday, March 30, from 11 a.m. to noon CT. Read MoreMar 22, 2021
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Chemo for cancer lowers dementia risk
Cancer chemotherapy lowered risk of Alzheimer’s disease and other neurocognitive disorders that disproportionately affect older people. Read MoreMar 22, 2021
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Register for colorectal cancer awareness webinar March 24
Join Health Plus and Stephanie McAbee, assistant professor of medicine in the Division of Gastroenterology, as they present the latest in colorectal cancer facts, risk reduction and screening guidelines on Wednesday, March 24, from noon to 12:50 p.m. Read MoreMar 3, 2021
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Vitamin D activation and cancer risk
Vitamin D protection against colon cancer varies according to parathyroid hormone response, particularly among women. Read MoreJan 7, 2021
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Hot spots identified for colorectal cancer mortality rates among young women
Women diagnosed with early-onset colorectal cancer have a greater risk of dying from the disease depending upon their county of residence, according to a study published in Clinical and Translational Gastroenterology. Read MoreNov 23, 2020
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New drug for metastatic colorectal cancer enters phase 3 trial
A new therapy for metastatic colorectal cancer that has been granted fast track designation by the U.S. Food and Drug Administration is being tested in a phase 3 clinical trial at Vanderbilt-Ingram Cancer Center. Read MoreNov 18, 2020
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New markers of colorectal cancer risk
Vanderbilt epidemiologists identified new markers for colorectal cancer risk and characterized a previously unidentified tumor suppressor that regulates overall tumor volume in vivo. Read MoreOct 29, 2020
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Preserving gut mucus architecture
A new method that keeps microbes and gut cells together will be useful for studies of complex host-microbe interactions and for analysis of clinical specimens. Read MoreOct 20, 2020
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Blocking tumor ‘signals’ and ‘fuel’
Combining two drugs reduced colorectal cancer cell growth in vitro and in an animal model, suggesting the combination may be a promising treatment for patients. Read MoreAug 25, 2020