Chemotherapy

Vanderbilt researchers have developed an active machine learning approach to predict the effects of tumor variants of unknown significance, or VUS, on sensitivity to chemotherapy. Characterizing VUS can maximize clinical care and precision medicine for each patient. Read More

Steven Townsend, associate professor of chemistry, and Fang Yan, research professor of pediatrics and cell and development biology, have discovered how a sugar in human breast milk mitigates damage to the small intestines caused by chemotherapy-induced mucositis. Read More

Vanderbilt researchers discover that protein-coated nanoparticles kill more than half of cancer cells in the blood of patients with advanced chemo-resistant colon cancer. Est. reading time: 2.5 mins. Read More

Validation of cognitive complaints appears to improve mood in patients with persistent chemotherapy-cognitive impairment, Vanderbilt researchers report. Read More

Vanderbilt biochemists have discovered that the protein RADX has different biological effects at sites of DNA synthesis, depending on the cellular conditions — even though it works the same way in both stressed and unstressed cells. Read More

Cancer chemotherapy lowered risk of Alzheimer’s disease and other neurocognitive disorders that disproportionately affect older people. Read More

Structural details of a protein that removes DNA lesions shed light on fundamental mechanisms of DNA repair. Read More

A multicenter study led by Vanderbilt University Medical Center (VUMC) investigators found that pancreatic cancer patients who underwent surgery and received chemotherapy lived longer and had fewer cancer recurrences in other parts of the body than patients who also received chemoradiation therapy. Read More

Combining inhibitors of the BMP signaling pathway with standard chemotherapy drugs may overcome drug resistance in ovarian cancer. Read More

Phila Hach recently celebrated her 89th birthday and she has had much to celebrate over the years. Read More

Many women who receive chemotherapy for breast cancer report problems with their thinking, memory and attention after treatment. Read More

Drugs that target DNA damage improve ovarian cancer cell response to platinum chemotherapies, suggesting new therapeutic opportunities. Read More

Vanderbilt investigator Anthony Daniels has received a grant from the Knights Templar Eye Foundation to develop new, safe and effective treatments for retinoblastoma, the most common ocular cancer in children. Read More

A Nashville-based dietitian who lost her mother to cancer is using the power of social media to raise funds for chemo care bags for cancer patients. Read More

A team of biomedical engineers has developed a new "tumor-in-a-dish" technology that promises to improve the effectiveness of chemotherapy. Read More

A genetic variant is associated with toxicity of the chemotherapy drug melphalan, and could guide individualized dosing for the medication. Read More

The nuclear receptor TR3 contributes to ovarian cancer cell death in response to platinum-based chemotherapy – and may be a good target for overcoming cell resistance to certain treatments. Read More

Researchers are developing imaging methods to predict patient outcome early in the course of chemotherapy for breast cancer – to allow clinicians to adjust therapy for patients who are not responding. Read More

Combining another drug with platinum-based chemotherapies may be more effective against ovarian cancer. Read More

A study led by Vanderbilt-Ingram Cancer Center investigators has identified a gene expression pattern that may explain why chemotherapy prior to surgery isn’t effective against some tumors and suggests new therapy options for patients with specific subtypes of breast cancer. Read More