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Charles Hong Archives

Goal of new tissue-chip research is to assess efficacy of novel epilepsy drugs

Sep. 20, 2017—An interdisciplinary team of Vanderbilt University researchers has received a two-year, $2-million federal grant to develop an “organ-on-chip” model for two genetic forms of epilepsy.

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NOTCH1 role in heart development

Jul. 3, 2017—The identification of a genetic culprit for hypoplastic left heart syndrome could lead to new treatments for the condition.

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Organ-on-a-chip mimics heart’s biomechanical properties

Feb. 22, 2017—Scientists at Vanderbilt University have created a three-dimensional organ-on-a-chip that can mimic the heart’s amazing biomechanical properties in order to study cardiac disease, develop heart drugs.

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New method aids heart disease studies, drug discovery efforts

Jan. 14, 2016—A team of Vanderbilt investigators developed a new method for rapidly generating heart muscle cells from stem cells.

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New lead for ovarian cancer treatment

Dec. 10, 2015—Combining inhibitors of the BMP signaling pathway with standard chemotherapy drugs may overcome drug resistance in ovarian cancer.

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Collaboration seeks to develop new therapies for bone, other diseases

Oct. 1, 2015—La Jolla Pharmaceutical Co. and Vanderbilt University have signed a research and license agreement covering Vanderbilt’s research program and intellectual property rights related to compounds that block bone morphogenetic protein (BMP) type-I receptors. The compounds have therapeutic potential in a broad range of diseases, including rare genetic disorders.

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Delivering cells for heart repair

Jul. 10, 2015—A polymer hydrogel material developed by Vanderbilt scientists improved the delivery of stem cells for heart repair.

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Cancer signaling pathway blocker

Apr. 3, 2015—Researchers at Vanderbilt University have discovered a new way to inhibit Hedgehog (Hh) signaling, an important regulatory pathway for vertebrate development – and cancer.

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Growth factor blockade targets breast tumors

Aug. 14, 2014—Inhibition of BMP growth factor signaling reduces breast tumor burden and metastasis.

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Fishing for new anti-cancer drugs

Sep. 18, 2013—Vanderbilt investigators used an in vivo screen in zebrafish to identify a potential new anti-cancer drug.

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Vanderbilt’s Hong, Niswender elected to ASCI

Apr. 18, 2013—Charles Hong, M.D., Ph.D., and Kevin Niswender, M.D., Ph.D., have been elected to membership in the American Society of Clinical Investigation (ASCI), one of the nation’s most respected medical honor societies.

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Move out, cholesterol

Dec. 8, 2011—Compounds developed at Vanderbilt could offer a whole new way to treat atherosclerosis.

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