Cell Reports

Vanderbilt researchers have demonstrated that a cluster of microRNAs — small pieces of RNA that regulate gene expression — work in a type of immune cells called macrophages to help protect against metabolic defects in obesity. Read More

By Marissa Shapiro THE IDEA The human brain is organized in functional networks—connected brain regions that communicate with each other through dedicated pathways. That is how we perceive our senses, how the body moves, how we are able to remember the past and plan for the future. The “default mode” network is the part of... Read More

By Marissa Shapiro THE IDEA The human brain is organized in functional networks—connected brain regions that communicate with each other through dedicated pathways. That is how we perceive our senses, how the body moves, how we are able to remember the past and plan for the future. The “default mode” network is the part of... Read More

Collaboration across seven laboratories, in five institutions, across three countries and led by Vanderbilt researchers addresses fundamental questions about the organization and evolution of the human brain. Est. reading time: 1.75 mins. Read More

The invading pathogen Salmonella, a common cause of food poisoning, can change its metabolism to overcome host resistance to its colonization. Read More

Researchers discover how a protein may treat schizophrenia, including reversing working memory deficits, a hallmark of schizophrenia for which there is currently no treatment. Read More

Lisa Monteggia and her lab have identified how specific neurons in the hippocampus work to produce ketamine’s antidepressant action. Est. reading time: 2 mins. Read More

A technology developed at Vanderbilt has led to the discovery of an “ultra-potent” monoclonal antibody against multiple variants of SARS-CoV-2, the virus responsible for COVID-19, including the delta variant. Read More

Even in the absence of brain activity, nerve cells can turn on gene expression that is important for antidepressant effects. This novel finding from Lisa Monteggia gives researchers a more fundamental understanding of the brain’s mechanistic function for better therapeutics. Est. reading time: 2.5 mins. Read More

L.J. Zwiebel and his lab show that mosquito larvae, the age group targeted for most control programs, are far more sophisticated than previously thought. Est. reading time: 2 mins. Read More

Fluid build-up in the brain — hydrocephalus — increases pressure and risk for brain damage; Vanderbilt researchers have now identified genes and signaling pathways associated with the condition. Read More

Vanderbilt Vaccine Center researchers have isolated monoclonal antibodies against hantaviruses, an emerging source of human disease with pandemic potential. Read More

William Tansey and colleagues identified proteins that interact with the cancer drug target WDR5 and are important for cancer cell growth. Read More

Understanding how bacteria evolve resistance to antibiotics and host stresses could guide the development of more effective antimicrobial therapeutics. Read More

Combining studies of genetically diverse mouse populations and human data led to the identification of a gene associated with cognitive decline and brain changes in Alzheimer’s disease. Read More

Deborah Lannigan and colleagues identify a key regulator of the estrogen receptor and suggest that its downregulation by oral contraceptives may increase oxidative stress and DNA damage, a common cause of cancer. Read More

This week researchers at Vanderbilt University Medical Center (VUMC), the University of North Carolina at Chapel Hill and Gilead Sciences reported that remdesivir potently inhibited SARS-CoV-2, the virus which causes COVID-19, in human lung cell cultures and that it improved lung function in mice infected with the virus. Read More

After discovering a new mechanism for DNA damage repair last year, Vanderbilt biochemists now provide direct evidence for how it works. Read More

Vanderbilt cell biologists have developed an unbiased, quantitative framework for evaluating single-cell data. Read More

Dylan Burnette and colleagues have discovered that two forms of the molecular motor protein myosin have distinct roles in regulating cell shape during cell division. Read More