Basic Sciences

Quynh Anh Nguyen, assistant professor of pharmacology, is the first Vanderbilt faculty member to be awarded the highly competitive Klingenstein Fellowship in Neuroscience since 1985. Her research aims to unravel the mysteries of epilepsy by focusing on how specific cells in the brain contribute to or suppress the hyperexcitability in neural circuits that are thought to be involved in the disorder’s spontaneous seizures. Read More

A group of researchers from the lab of Larry Marnett, the Mary Geddes Stahlman Professor of Cancer Research, recently paired a precisely targeted imaging agent to an anticancer agent and found that they could specifically attack cancer cells and not normal cells with it. Their work was performed in collaboration with School of Engineering faculty members Craig Duvall and Rebecca Cook, and was published in Molecular Pharmaceutics in April 2025. Read More

Targeting ncRNAs with drugs presents a much larger therapeutic opportunity than targeting proteins, but the currently available drug discovery tools are slow and computationally intensive. Assistant Professor of Molecular Physiology and Biophysics and core member of the Center for Applied AI in Protein Dynamics Carlos Oliver is working with collaborators to unlock the untapped potential of ncRNAs, as they are a promising family of targets for the development of novel small-molecule therapeutics. Read More

Crucial research by Neil Osheroff and his lab leads to approval of the first new class of antibacterial drugs in decades. The drug, gepotidacin, developed by GlaxoSmithKline under the brand name Blujepa, will be available starting later this year, potentially bringing relief to thousands of women who struggle with uncomplicated urinary tract infections. Read More

Though Helicobacter pylori lives in the guts of about half of the world's adults, infections can go undetected for decades. The problem: the bacteria is the primary risk factor for gastric cancer, and one strain of the germ carries a higher risk. Vanderbilt researchers Tim Cover and Jennifer Shuman analyzed how the genetic makeup of H. pylori strains affects how they change the molecular makeup of gut tissues and lead to gastric cancer. Read More

Stephanie Wankowicz, Assistant Professor of Molecular Physiology and Biophysics and Principal Investigator at the Wankowicz Lab (Submitted photo) When proteins are on the move, the way they wiggle, jiggle and form shapes within a cell informs the jobs they perform. From simple interactions, to making chemical reactions happen, to helping… Read More

The laboratory of Ege Kavalali, professor and chair of the Department of Pharmacology, published a new paper in Nature Communications that determined that liquid-liquid phase separation plays a key role within the nanostructure of synapses, and that its disruption affects evoked but not spontaneous neurotransmission. Read More

A recent pair of papers from the Vanderbilt University labs of Benjamin Spiller, associate professor of pharmacology, and Scott Smith, associate professor of medicine, dig into how peanut allergies are provoked and providing support for the use of a potential treatment option: hypoallergens. Both papers were published in February in the Journal of Allergy and Clinical Immunology. Read More

Medicine often takes a one-size-fits-all approach, but a disorder’s root cause can vary. Vanderbilt researchers have found that, for people with long QT syndrome, a heart condition that causes an irregular heartbeat, a more tailored approach could be beneficial. The research, led by Vanderbilt University Professor of Biochemistry and Vice Dean of Basic Sciences Charles Sanders and Northwestern University Professor and Chair of Pharmacology Dr. Al George, was published in PNAS in February 2025. Read More

Submissions are open for pre-proposals for the 2025 National Institutes of Health S10 Shared and High-End Instrumentation Grant programs, which fund state-of-the-art shared research equipment. Internal pre-proposals are due by April 1, 2025, to allow institutional review before the June 2 NIH deadline, with guidance available from OVPRI and VBS. Read More

Vestigo is a print and online magazine published by the Vanderbilt University School of Medicine Basic Sciences. Published once a year, Vestigo provides an in-depth view of research that’s happening in our community, highlights trainee accomplishments, and celebrates the successes of our staff and faculty. Read More

Researchers at the Warren Center for Neuroscience Drug Discovery have detailed the successful drug discovery of a Phase I Single Ascending Dose clinical trial of VU319, a drug for memory loss in people with Alzheimer’s disease and schizophrenia. Read More

Doug Mitchell has been appointed the holder of the William Kelly Warren Sr. Chair in Biochemistry and professor of chemistry and director of the Vanderbilt Institute for Chemical Biology. Read More

The lab of Hassane Mchaourab, director of the Center for Applied Artificial Intelligence in Protein Dynamics and professor of molecular physiology and biophysics, has developed a methodological blueprint that couples experimental double electron–electron resonance spectroscopy with an AI approach to help describe the conformational landscapes of a diverse spectrum of cell membrane transporters. Read More

Yi Ren’s most recent paper, published in eLife, describes the structure of a protein complex involved in mRNA export that sheds light on the underlying molecular mechanism of mRNA export and the role it plays during infection by herpes viruses. Read More

Led by Craig W. Lindsley, Vanderbilt drug discovery experts set out to develop a backup drug candidate to improve memory loss in people with Alzheimer’s disease. Read More

Christian de Caestecker, a Ph.D. student in the lab of Ian Macara, Louise B. McGavock Professor and chair of the Department of Cell and Developmental Biology, has proposed and validated a mechanism that addresses a decades-old mystery surrounding epithelial cells. Read More

Carterra Inc. and the Vanderbilt University School of Medicine Basic Sciences announced the addition of the Carterra LSAXT label-free interaction analysis platform to the Center for Structural Biology. Vanderbilt and Vanderbilt University Medical Center researchers will be able to discover and characterize large molecules including antibodies. Read More

Amanda Linkous, research associate professor of pharmacology, has been awarded a research grant from the Merck Research Laboratories Scientific Engagement and Emerging Discovery Science (SEEDS) program to identify therapeutic intervention points to prevent the colonization and proliferation of small cell lung cancer and non-small cell lung cancer in the lung and brain. Read More

Research from the lab of Bill Tansey and other collaborators tested protein inhibitors called WINi against a panel of cancer cells and found that they have strong action against blood cancers and synergize with an FDA-approved cancer drug. Read More