Antidepressants

Ege Kavalali and Heidi Hamm collaborated to discover a signaling pathway for how spontaneous release of neurotransmitters can be selectively regulated without disrupting evoked action potentials. Read More

A study by Vanderbilt researchers sheds light on how current antidepressant drugs work and suggests a new drug target in depression. Read More

Vanderbilt researchers push research on ketamine’s role as a rapid antidepressant another step forward. This work opens avenues for new therapeutics for half of people for whom today’s antidepressants don’t work. Read More

Lisa Monteggia and her lab have identified how specific neurons in the hippocampus work to produce ketamine’s antidepressant action. Est. reading time: 2 mins. Read More

Even in the absence of brain activity, nerve cells can turn on gene expression that is important for antidepressant effects. This novel finding from Lisa Monteggia gives researchers a more fundamental understanding of the brain’s mechanistic function for better therapeutics. Est. reading time: 2.5 mins. Read More

Lisa Monteggia leads discovery of the gene responsible for ketamine’s long-term effects with implications for antidepressant therapeutics. Est. reading time: 2.5 mins. Read More

Research led by Lisa Monteggia reveals that ketamine provides antidepressant effects by blocking key neural pathway. Est. reading time: 3 mins. Read More

Researchers at VUMC have taken a major step that could ultimately facilitate development of a new class of antidepressants which may relieve symptoms more rapidly and effectively and with fewer side effects than current medications. Read More

A national study is seeking to determine whether genetic testing can help physicians choose the best drugs for their patients to relieve pain and depression. Read More

Vanderbilt investigators have discovered how antidepressant medicines that block serotonin uptake can increase bleeding risk. Read More

A Vanderbilt University study published today in the Journal of Clinical Psychiatry may help patients prescribed higher doses of certain antidepressants feel better about attributed cardiac risks. Read More

Antidepressant use during pregnancy is common. Fetal exposure to the class of antidepressants known as selective serotonin reuptake inhibitors (SSRIs) is associated with the life-threatening condition PPHN (persistent pulmonary hypertension of the newborn), but a causal link has not been established. Read More

Dynamic measurements of the bacterial leucine transporter shed light on the transporters that play roles in neuropsychiatric and addiction disorders. Read More

A new Vanderbilt University Medical Center study shows there is no evidence that the risk of suicide differs with two commonly prescribed antidepressants prescribed to children and adolescents. Read More

A new mouse model offers the ability to better test how selective serotonin reuptake inhibitors (SSRIs) work and could lead to the development of new classes of anti-depressants. Read More