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Health and Medicine

Diabetes trial sets bar high for retaining research subjects

Jan. 5, 2012—Loren Kirkpatrick has been enrolled in the Diabetes Control and Complications Trial (DCCT) at Vanderbilt’s Diabetes Center for nearly half of her adult life. Diagnosed with type 1 diabetes in 1982 at age 34, Kirkpatrick enrolled as the study’s first patient in 1983. Now Kirkpatrick has become the symbol of what Vanderbilt researchers hope is...

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Fishing for heart attack repair tools

Jan. 5, 2012—Managing myocardial infarction – and the resulting heart failure – remains a clinical challenge. To search for chemicals that can stimulate cardiac muscle cell production, Vanderbilt Institute of Chemical Biology investigators led by Tao Zhong, Ph.D., Terri Ni, Ph.D., and Eric Rellinger, M.D., turned to a novel drug discovery tool: zebrafish. The researchers visually screened...

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Clues to flattened faces

Jan. 5, 2012—Mutations in the Jagged1 gene cause Alagille syndrome, an inherited disorder that affects the liver, heart, kidneys and facial structure. Patients with Alagille syndrome often have a prominent forehead, a flattened midface and a prominent chin; some have a cleft palate. To investigate how mutations in Jagged1 cause facial anomalies, Steven Goudy, M.D., and colleagues...

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Study uses art to spur patients to walk after surgery

Jan. 5, 2012—Following cardiac surgery, patients are encouraged to get out of bed and walk as soon as possible, a daunting task to many who may be experiencing pain or a reluctance to exert themselves. Protocol has cardiac surgery patients walk three laps around the halls of 5 South and 6 South of Vanderbilt University Hospital three...

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Training addresses returning service members’ mental health needs

Dec. 21, 2011—A Vanderbilt-led workshop for military health care providers could lead to more post-deployment mental health referrals.

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Cholesterol-lowering drugs may reduce mortality for influenza patients

Dec. 19, 2011—Statins, traditionally known as cholesterol-lowering drugs, may reduce mortality among patients hospitalized with influenza, according to a new study released online by The Journal of Infectious Diseases.

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Clues to skeletal form in ‘feelgood’ fish

Dec. 16, 2011—Ela Knapik, associate professor of medicine, and colleagues are using zebrafish to explore the molecular and cellular mechanisms that cause birth defects of the face and skeleton.

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Divvying up chromosomes

Dec. 16, 2011—Mitosis, or the separation of chromosomes during cell division, is driven by dynamic interactions between the kinetochore region on chromosomes and string-like structures called microtubules. A number of proteins, including the enzyme Cdk1, regulate these interactions, but it is unclear what kinetochore components such enzymes work upon. Kathy Gould, professor of cell and developmental biology,...

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“Extractionator” could bring high-tech medical diagnostics to rural areas

Dec. 16, 2011—The Bill and Melinda Gates Foundation has given them $1 million to three Vanderbilt scientists to develop a point-of-care sample collection and preparation product that could bring advanced medical diagnostic testing to the third world.

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New schizophrenia drug candidates entering prep for first-in-human testing

Dec. 15, 2011—The progression of new drug candidates for schizophrenia with partner Janssen Pharmaceutica is the latest evidence that a new collaborative model for drug discovery pioneered at Vanderbilt may help identify and develop innovative candidate drugs for treatment of major brain disorders.

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Young stem cells counter kidney aging

Dec. 15, 2011—Young bone marrow cells alleviate aging-related kidney changes in mice.

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Divvying up chromosomes

Dec. 15, 2011—Protein helps ensure proper division of chromosomes during cell division.

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