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Author: Leigh MacMillan

Studies shed new light on how nitric oxide is produced

Jan. 20, 2012—The discovery of a previously unrecognized and pivotal role of enzyme ASL in nitric oxide production could potentially lead to new therapies for babies with pulmonary hypertension.

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Pumping up the pancreas in pregnancy

Jan. 20, 2012—A strain of mutant mice provide a novel model for studying glucose intolerance and gestational diabetes during pregnancy and suggest that certain molecules may be useful for therapeutic applications.

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Fishing for heart attack repair tools

Jan. 5, 2012—Managing myocardial infarction – and the resulting heart failure – remains a clinical challenge. To search for chemicals that can stimulate cardiac muscle cell production, Vanderbilt Institute of Chemical Biology investigators led by Tao Zhong, Ph.D., Terri Ni, Ph.D., and Eric Rellinger, M.D., turned to a novel drug discovery tool: zebrafish. The researchers visually screened...

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Clues to flattened faces

Jan. 5, 2012—Mutations in the Jagged1 gene cause Alagille syndrome, an inherited disorder that affects the liver, heart, kidneys and facial structure. Patients with Alagille syndrome often have a prominent forehead, a flattened midface and a prominent chin; some have a cleft palate. To investigate how mutations in Jagged1 cause facial anomalies, Steven Goudy, M.D., and colleagues...

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Clues to skeletal form in ‘feelgood’ fish

Dec. 16, 2011—Ela Knapik, associate professor of medicine, and colleagues are using zebrafish to explore the molecular and cellular mechanisms that cause birth defects of the face and skeleton.

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Move out, cholesterol

Dec. 8, 2011—Compounds developed at Vanderbilt could offer a whole new way to treat atherosclerosis.

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Ecstasy drug produces lasting toxicity in the brain

Dec. 6, 2011—Recreational use of the "rave" drug Ecstasy is associated with chronic changes in the human brain.

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Drug target for deadly heart infection

Dec. 1, 2011—Structural biology studies of a bacterial protein suggest a new target for treating life-threatening heart infection.

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Skeletal defects in genetic disorder

Nov. 18, 2011—A new mouse model provides a tool for testing novel therapeutic approaches for neurofibromatosis.

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Averting a future oncologist shortage

Nov. 11, 2011—Providing increased mentorship, research opportunities and a nurturing, intellectual environment during fellowship training may help reduce a projected shortage of academic hematologists and oncologists.

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Balancing act in the gut

Nov. 11, 2011—Vanderbilt researchers have identified an antigen important to balancing the immune response to bacteria in the gut.

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Let there be light and melatonin

Nov. 4, 2011—Light and the hormone melatonin may play important roles in the developing brain.

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