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Author: Leigh MacMillan

Kidney woes during heart failure

Nov. 8, 2012—Levels of the protein NGAL may be a good predictor of worsening kidney function in patients with acute heart failure.

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Protein’s length, flexibility key to infection

Oct. 31, 2012—The structural architecture of the reovirus attachment protein is required for efficient reovirus infection of host cells.

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Stomach bug alters tumor suppressor

Oct. 23, 2012—The stomach bug Helicobacter pylori increases forms of a protein that promote tumor development, perhaps explaining how it elevates risk for gastric cancer.

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Gene regulation found to play role in pulmonary hypertension

Oct. 18, 2012—New findings from Vanderbilt researchers may explain why only some individuals who have inherited mutations that increase risk for pulmonary hypertension actually develop the disease.

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Setting traps to probe gene function

Oct. 18, 2012—A new method for creating genetic mutations that can be activated at certain times or in specific tissues will enable studies to probe gene function.

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Amish aid search for Alzheimer’s genes

Oct. 11, 2012—An analysis of Amish populations revealed novel risk genes for late-onset Alzheimer disease.

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Host proteins can control HIV infection

Oct. 5, 2012—The protein APOBEC3G contributes to spontaneous control of HIV-1 in vivo and may provide therapeutic benefits.

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Proteins help flip tumor’s invasive switch

Oct. 4, 2012—Vanderbilt investigators have identified how two key components of cancer's invasive "switch" — the series of signaling events that turn on a tumor cell’s invasive behavior — work together.

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Cell entry ports for cold virus

Sep. 25, 2012—The respiratory virus HMPV uses its fusion (F) protein – which interacts with cellular receptors called integrins – to bind to and enter target cells.

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How ‘Jedi’ disposes of dead neurons

Sep. 19, 2012—The protein Syk is essential for clearing away neuron “corpses” in the developing peripheral nervous system.

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Cells with LIP eat their neighbors

Sep. 13, 2012—A transcription factor called LIP is capable of causing one cell to consume another.

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New doctoral students welcomed

Sep. 6, 2012—Vanderbilt University Medical Center welcomed 109 new doctoral students into the scientific community last week in the third annual “Simple Beginnings” ceremony.

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